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109-70-6 - 1-Bromo-3-chloropropane, 99% - Trimethylene bromochloride - A11395 - Alfa Aesar

A11395 1-Bromo-3-chloropropane, 99%

CAS Number
109-70-6
Synonyms
Trimethylene bromochloride

Size Price ($) Quantity Availability
100g 14.40
250g 23.59
500g 36.67
1000g 61.49
5000g 198.72
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1-Bromo-3-chloropropane, 99%

MDL
MFCD00000998
EINECS
203-697-1

Chemical Properties

Formula
Cl(CH2)3Br
Formula Weight
157.44
Melting point
-59°
Boiling Point
142-145°
Flash Point
>140°(284°F)
Density
1.598
Refractive Index
1.4855
Solubility
Miscible with alcohols, chlorofom and ether. Immiscible with water.

Applications

1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations.

Notes

Incompatible with strong oxidizing, reducing agents, amines, nitrides, azo/diazo compounds, alkali metals and epoxides.

Literature References

Fan, X.; Sokorai, K. J. Formation of trichloromethane in chlorinated water and fresh-cut produce and as a result of reaction with citric acid. Postharvest Biol. Technol. 2015, 109, 65-72.

Donnier-Maréchal, M.; Carato, P.; Le Broc, D.; Furman, C.; Melnyk, P. Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands. Eur. J. Med. Chem. 2015, 92, 575-582.

GHS Hazard and Precautionary Statements

Hazard Statements: H331-H302-H402-H412

Toxic if inhaled. Harmful if swallowed. Harmful to aquatic life. Harmful to aquatic life with long lasting effects.

Precautionary Statements: P261-P273-P264-P304+P340-P311-P301+P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wash thoroughly after handling. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
605278
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2903.79
TSCA
Yes
RTECS
TX4113000

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