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A11395 1-Bromo-3-chloropropane, 99%

CAS Number
109-70-6
Synonyms
Trimethylene bromochloride

Stock No. Size Price ($) Quantity Availability
A11395-22 100g 16.30
A11395-30 250g 24.60
A11395-0B 1000g 64.00
A11395-0I 5000g 240.00
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1-Bromo-3-chloropropane, 99%

MDL
MFCD00000998
EINECS
203-697-1

Chemical Properties

Formula
Cl(CH2)3Br
Formula Weight
157.44
Melting point
-59°
Boiling Point
142-145°
Flash Point
>140°(284°F)
Density
1.598
Refractive Index
1.4855
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with alcohols, chlorofom and ether. Immiscible with water.

Applications

1-Bromo-3-chloropropane is used in the preparation active pharmaceutical ingredient intermediate such as gemfibrozil and reproterol. It is also involved in the preparation of cardiovascular diseases and analgesic drugs materials. It is utilized as a phase separation reagent for the isolation of ribonucleic acid (RNA) in high quality. It is considered as a replacement of chloroform in nucleic acid separations.

Notes

Incompatible with strong oxidizing, reducing agents, amines, nitrides, azo/diazo compounds, alkali metals and epoxides.

Literature References

Fan, X.; Sokorai, K. J. Formation of trichloromethane in chlorinated water and fresh-cut produce and as a result of reaction with citric acid. Postharvest Biol. Technol. 2015, 109, 65-72.

Donnier-Maréchal, M.; Carato, P.; Le Broc, D.; Furman, C.; Melnyk, P. Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands. Eur. J. Med. Chem. 2015, 92, 575-582.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H302-H331-H335-H341

Combustible liquid. Harmful if swallowed. Toxic if inhaled. May cause respiratory irritation. Suspected of causing genetic defects.

Precautionary Statements: P201-P202-P210-P235-P261-P264b-P270-P271-P281-P301+P312-P304+P340-P308+P313-P311-P330-P370+P378q-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep cool. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Use personal protective equipment as required. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF exposed or concerned: Get medical advice/attention. Call a POISON CENTER or doctor/physician. Rinse mouth. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
605278
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2903.79
TSCA
Yes
RTECS
TX4113000

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