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434-45-7 - 2,2,2-Trifluoroacetophenone, 98% - Phenyl trifluoromethyl ketone - Trifluoroacetylbenzene - A11403 - Alfa Aesar

A11403 2,2,2-Trifluoroacetophenone, 98%

CAS Number
434-45-7
Synonyms
Phenyl trifluoromethyl ketone
Trifluoroacetylbenzene

Size Price ($) Quantity Availability
5g 33.12
25g 83.02
100g 234.80
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2,2,2-Trifluoroacetophenone, 98%

MDL
MFCD00000420
EINECS
207-103-1

Chemical Properties

Formula
C8H5F3O
Formula Weight
174.12
Melting point
-40°
Boiling Point
165-166°
Flash Point
42°(108°F)
Density
1.240
Refractive Index
1.4595

Literature References

Trifluoromethyl ketones undergo selective C-F bond cleavage with Mg in the presence of TMSCl, providing a convenient synthesis of 2,2-difluoro enol silanes: Chem. Commun., 1323 (1999).

/n

Olefination with methanesulfonyl chloride, promoted by KF in DMF, gives ɑ -(trifluoromethyl)styrene in 92% yield: J. Org. Chem., 59, 2898 (1994).

/n

Reaction with Dimethyl­ acetyl­enedicarboxyl­ate, A11437, in the presence of triphenylphosphine, gives a highly-functionalized -butyrolactone: J. Org. Chem., 61, 4516 (1996):

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In the presence of potassium monopersulfate (Oxone ), catalyzes the epoxidation of allylic alcohols via the in situ formed dioxirane: Tetrahedron, 56, 989 (1999).

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In the presence of KO-t-Bu, acts as a nucleophilic trifluoromethylating agent, converting carbonyl compounds to trifluoromethyl alcohols: Tetrahedron Lett., 44, 1055 (2003).

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GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1866286
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2914.70
TSCA
Yes

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