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Stock No. | Size | Price ($) | Quantity | Availability |
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A11410-09 | 10g | 41.10 |
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A11410-18 | 50g | 147.00 |
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A11410-30 | 250g | 666.00 |
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(Acetylmethylene)triphenylphosphorane is used as a Wittig reagent in synthetic chemistry, especially for the synthesis of functionalized pyrrolidines and cyclobutanones. It plays as a vital role in asymmetric allylboration for enantioselective synthesis of (+)-awajanomycin.It is also employed as a reactant in the preparation of 1,2-dioxanes with antitrypanosomal activity. Further, it is used in the preparation of amphibian pyrrolizidine alkaloids through allylic aminations and silicon-containing acyclic dienone musk odorants. In addition to this, it is involved in Domino Suzuki/Heck coupling reactions to prepare fluorenylidenes.
Stabilized ylide which converts aldehydes to methyl ɑß-enones (see Appendix 1). Metallation with n-BuLi and alkylation, followed by Wittig reaction with an aldehyde provides a route to ɑß-unsaturated ketones: J. Org. Chem., 38, 4082 (1973); Synth. Commun., 8, 579 (1979):
For C-acylation followed by oxidation of the resulting diacylphosphoranes to give 1,2,3-triketones, see N,O-Bis(trimethylsilyl)acetamide, L00183.
Zhang, Y.; Wu, S.; Wang, S.; Fang, K.; Dong, G.; Liu, N.; Miao, Z.; Yao, J.; Li, J.; Zhang, W.; Sheng, C.; Wang, W. Divergent Cascade Construction of Skeletally Diverse Privileged Pyrazole-Derived Molecular Architectures. Eur. J. Org. Chem. 2015, 2015 (9), 2030-2037.
Chu, S.; Wallace, S.; Smith, M. D. A Cascade Strategy Enables a Total Synthesis of (-)-Gephyrotoxin. Angew. Chem. Int. Ed. 2014, 53 (50), 13826-13829.