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89-00-9 - Pyridine-2,3-dicarboxylic acid, 99% - Quinolinic acid - A11414 - Alfa Aesar

A11414 Pyridine-2,3-dicarboxylic acid, 99%

CAS Number
89-00-9
Synonyms
Quinolinic acid

Size Price ($) Quantity Availability
25g 22.45
100g 57.99
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Pyridine-2,3-dicarboxylic acid, 99%

MDL
MFCD00006295
EINECS
201-874-8

Chemical Properties

Formula
C7H5NO4
Formula Weight
167.12
Melting point
ca 188° dec.
Solubility
Soluble in water (partly), alkalies, dilute aqueous base, DMSO, and alcohol (slightly).

Applications

Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an “excitotoxic” metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

MF Beal,; RJ Ferrante,; KJ Swartz,; NW Kowall. Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. The Journal of Neuroscience,. 1991, 11(6), 1649-1659.

Dr Melvyn P. Heyes PhD,; Bruce J. Brew MD,; Alex Martin PhD,; Richard W. Price MD,; Andres M. Salazar MD.Quinolinic acid in cerebrospinal fluid and serum in HIV-1 Infection: Relationship to clinical and neurological status. Annals of Neurology. 1991 , 29 (2),202-209.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,8073
Beilstein
137110
Harmonized Tariff Code
2933.39
TSCA
Yes
RTECS
US7967250

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