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A11469 6-Fluoro-2-methylquinoline, 98+%

CAS Number
1128-61-6
Synonyms
6-Fluoroquinaldine

Stock No. Size Price ($) Quantity Availability
A11469-06 5g 68.70
A11469-14 25g 255.00
A11469-22 100g 943.00
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6-Fluoro-2-methylquinoline, 98+%

MDL
MFCD00041233
EINECS
214-439-2

Chemical Properties

Formula
C10H8FN
Formula Weight
161.18
Melting point
52-56°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in Chloroform.

Applications

Metal-free transfer hydrogenation of 6-fluoro-2-methylquinoline by employing several chiral Brønsted acid catalysts was carried out in combination with dihydropyridines as the hydride source in asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Hydrogenation product of 6-fluoro-2-methylquinoline is the key intermediate of the antibacterial agent.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Magnus Rueping,; Mirjam Stoeckel,; Erli Sugiono,; Thomas Theissmann. Asymmetric metal-free synthesis of fluoroquinolones by organocatalytic hydrogenation. Tetrahedron. 2010 , 6633,6565-6568.

Nadia M. Ahmad,; Jie Jack Li. Palladium in Quinoline Synthesis. Advances in Heterocyclic Chemistry. 2003, 841-30.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1281677
Harmonized Tariff Code
2933.49
TSCA
No

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