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373-61-5 - Boron trifluoride-acetic acid complex, 96% - A11471 - Alfa Aesar

A11471 Boron trifluoride-acetic acid complex, 96%

CAS Number
373-61-5
Synonyms

Size Price ($) Quantity Availability
250ml 51.91
1000ml 131.46
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Boron trifluoride-acetic acid complex, 96%

MDL
MFCD00036359
EINECS
206-768-5

Chemical Properties

Formula
BF3•2CH3CO2H
Formula Weight
187.91
Melting point
-47°
Boiling Point
143-146°
Flash Point
83°(181°F)
Density
1.353
Refractive Index
1.3670
Sensitivity
Moisture Sensitive
Solubility
It reacts with water.

Applications

It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff. It is also used as a desilylating agent. It is also been used in the protodesilylation of the phenyl group as part of the conversion of the dimethylphenylsilyl group into a hydroxyl group with retention of configuration.

Notes

Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Stable, but moisture sensitive. Incompatible with water, moist air, metals, strong oxidizing agents. Store under dry atmosphere.

Literature References

Masahito ochiai.; Kenzo sumi.; Eiichi fujita. Silicon-Assisted Ring Opening of Cyclopropyl Ketones with Boron Trifluoride-Acetic Acid Complex. Chemical and Pharmaceutical Bulletin. 1983, 31, (11), 3931-3938.

John v. Heid.; Robert levine. The Acylation of furan and thiophene with aliphatic anhydrides in the presence of boron trifluoride-etherate. J. Org. Chem. 1948, 13, (3), 409-412. Mild acid catalyst which has found use as a desilylating agent: Allylsilanes undergo desilylation, via ß-stabilized carbocations, to give alkenes with allylic rearrangement: Tetrahedron Lett., 446 (1979); J. Chem. Soc., Perkin 1, 3267 (1992). -Silyl tertiary alcohols undergo a pinacol-like rearrangement to give alkenes: Tetrahedron Lett., 22, 2321 (1981). Has been used in the protodesilylation of the phenyl group as part of the conversion of the dimethylphenylsilyl group into a hydroxyl group with retention of configuration: J. Chem. Soc., Perkin 1, 317 (1995). For reaction scheme, see Chlorodimethyl­phenyl­silane, A15638.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H302-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed. Combustible liquid.

Precautionary Statements: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
3686177
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2942.00
TSCA
Yes
RTECS
ED2280000

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