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It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff. It is also used as a desilylating agent. It is also been used in the protodesilylation of the phenyl group as part of the conversion of the dimethylphenylsilyl group into a hydroxyl group with retention of configuration.
Masahito ochiai.; Kenzo sumi.; Eiichi fujita. Silicon-Assisted Ring Opening of Cyclopropyl Ketones with Boron Trifluoride-Acetic Acid Complex. Chemical and Pharmaceutical Bulletin. 1983, 31, (11), 3931-3938.
John v. Heid.; Robert levine. The Acylation of furan and thiophene with aliphatic anhydrides in the presence of boron trifluoride-etherate. J. Org. Chem. 1948, 13, (3), 409-412.Mild acid catalyst which has found use as a desilylating agent: Allylsilanes undergo desilylation, via ß-stabilized carbocations, to give alkenes with allylic rearrangement: Tetrahedron Lett., 446 (1979); J. Chem. Soc., Perkin 1, 3267 (1992). -Silyl tertiary alcohols undergo a pinacol-like rearrangement to give alkenes: Tetrahedron Lett., 22, 2321 (1981). Has been used in the protodesilylation of the phenyl group as part of the conversion of the dimethylphenylsilyl group into a hydroxyl group with retention of configuration: J. Chem. Soc., Perkin 1, 317 (1995). For reaction scheme, see Chlorodimethylphenylsilane, A15638.
Hazard Statements: H227-H302-H314-H318
Combustible liquid. Harmful if swallowed. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P210u-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.