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A11477 3-Butyn-1-ol, 98%

CAS Number
927-74-2
Synonyms
4-Hydroxy-1-butyne

Stock No. Size Price ($) Quantity Availability
A11477-06 5g 37.00
A11477-14 25g 108.00
A11477-30 250g 1007.00
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3-Butyn-1-ol, 98%

MDL
MFCD00002955
EINECS
213-161-9

Chemical Properties

Formula
C4H6O
Formula Weight
70.09
Melting point
-63°
Boiling Point
129-130°
Flash Point
36°(96°F)
Density
0.927
Refractive Index
1.4405
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with alcohols and organic solvents. Immiscible with aliphatic hydrocarbon solvents.

Applications

3-butyn-1-ol is used in the study of a palladium-catalyzed coupling with beta-tetrionic acid bromide to prepare alkynyl substituted furanones. It is also used to prepare Markovnikov addition product. Further, it is used as an intermediate of an active pharmaceutical ingredient such as fexofenadine.

Notes

Incompatible with strong oxidizing agents, acids, acid anhydrides and copper.

Literature References

For examples of Sonogashira coupling with aryl iodides in the presence of trans-Dichlorobis(triphenyl­phosphine)­palladium(II)­, 10491, CuI and Et3N in acetonitrile, see: J. Med. Chem., 38, 1837 (1995).

The triflate ester cyclizes on prolonged reaction with Na trifluoroacetate in TFA to give cyclobutanone: Org. Synth. Coll., 6, 324 (1988).

Yin, S.; Dong, L.; Xia, Y.; Dong, B.; He, X.; Chen, D.; Qiu, H.; Song, B. Controlled self-assembly of a pyrene-based bolaamphiphile by acetate ions: from nanodisks to nanofibers by fluorescence enhancement. Soft matter 2015, 11 (22), 4424-4429.

Tan, W.; Li, Q.; Li, W.; Dong, F.; Guo, Z. Synthesis and antioxidant property of novel 1, 2, 3-triazole-linked starch derivatives via ‘click chemistry’. Int. J. Biol. Macromol. 2016, 82, 404-410.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H302-H312-H315-H319-H335

Flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P261-P264b-P270-P271-P280-P301+P312-P303+P361+P353-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
773710
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2905.29
TSCA
Yes
RTECS
ES0710000

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