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3-butyn-1-ol is used in the study of a palladium-catalyzed coupling with beta-tetrionic acid bromide to prepare alkynyl substituted furanones. It is also used to prepare Markovnikov addition product. Further, it is used as an intermediate of an active pharmaceutical ingredient such as fexofenadine.
For examples of Sonogashira coupling with aryl iodides in the presence of trans-Dichlorobis(triphenylphosphine)palladium(II), 10491, CuI and Et3N in acetonitrile, see: J. Med. Chem., 38, 1837 (1995).
The triflate ester cyclizes on prolonged reaction with Na trifluoroacetate in TFA to give cyclobutanone: Org. Synth. Coll., 6, 324 (1988).
Yin, S.; Dong, L.; Xia, Y.; Dong, B.; He, X.; Chen, D.; Qiu, H.; Song, B. Controlled self-assembly of a pyrene-based bolaamphiphile by acetate ions: from nanodisks to nanofibers by fluorescence enhancement. Soft matter 2015, 11 (22), 4424-4429.
Tan, W.; Li, Q.; Li, W.; Dong, F.; Guo, Z. Synthesis and antioxidant property of novel 1, 2, 3-triazole-linked starch derivatives via click chemistry. Int. J. Biol. Macromol. 2016, 82, 404-410.
Hazard Statements: H226-H315-H319-H335
Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P260-P201-P280g-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.