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As with 2-(Trifluoromethyl)aniline, A15072, the CF3 group promotes ionization of the amino group under basic conditions. Sodamide in liquid ammonia gives 4-aminobenzonitrile: Chem. Pharm. Bull., 23, 636 (1975)./n
Similarly, the CF3 group is activated towards nucleophiles. For use in the synthesis of 2-(4-aminophenyl)-substituted imidazolines and tetrahydropyrimidines, see: J. Heterocycl. Chem., 27, 803 (1990)./n
Hazard Statements: H227-H301-H319-H341
Combustible liquid. Toxic if swallowed. Causes serious eye irritation. Suspected of causing genetic defects.
Precautionary Statements: P273-P280h-P305+P351+P338-P309-P310a-P501a
Avoid release to the environment. Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Dispose of contents/container in accordance with local/regional/national/international regulations.