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A11482 Chloroacetic acid, 99%

CAS Number
79-11-8
Synonyms
Monochloroacetic acid

Stock No. Size Price ($) Quantity Availability
A11482-30 250g 30.00
A11482-0B 1000g 79.80
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Chloroacetic acid, 99%

MDL
MFCD00002683
EINECS
201-178-4

Chemical Properties

Formula
C2H3ClO2
Formula Weight
94.50
Melting point
60-63°
Boiling Point
189°
Flash Point
126°(258°F)
Density
1.404
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Solubility
Soluble in water, methanol, acetone, diethyl ether, benzene, chloroform and ethanol.

Applications

Chloroacetic acid is used in the production of pharmaceuticals, dyes, detergents, synthetic caffeine, glycine and thioglycolic acid, which acts as a stabilizer in PVC. It acts as a precursor to glyphosate and adrenaline. It also serves as a preservative and bacteriostat. Further, it is used as surface active agents and photosensitive chemicals. It is also used in the O-alkylation of salicylaldehyde and an active component in cosmetics. In addition, it is involved in the preparation of thickening agent carboxymethyl cellulose and carboxymethyl starch.

Notes

Incompatible with strong oxidizing agents, strong bases and strong reducing agents.

Literature References

A convenient one-pot alternative to the Knoevenagel or Horner-Wadsworth-Emmons reactions for the synthesis of ɑ-unsubstituted cinnamic acids involves the reaction of chloroacetic acid with dimethyl phosphite in the presence of sodium methoxide, and treatment of the resulting phosphonoacetate salt with a benzaldehyde: J. Org. Chem., 46, 2514 (1981):

For a more general version of this reaction, applicable to the synthesis of a variety of substituted acrylic acids, see 2-Bromopropionic acid, A17569 .

Scialdone, O.; Galia, A.; Sabatino, S.; Mira, D.; Amatore, C. Electrochemical Conversion of Dichloroacetic Acid to Chloroacetic Acid in a Microfluidic Stack and in a Series of Microfluidic Reactors. Chem. Electro. Chem. 2015, 2 (5), 684-690.

Teng, Y.; Liu, Y.; Jiang, J. Preparation of Carboxyl-End-Group Poly(methyl methacrylate) and Polystyrene with Low Polydispersity by Atom Transfer Radical Polymerization Initiated with Chloroacetic Acid. Asian J. Chem. 2015, 27 (9), 3254-3258.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H311-H314-H330-H335

Toxic if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage. Fatal if inhaled. May cause respiratory irritation.

Precautionary Statements: P260-P264b-P270-P271-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2112
Beilstein
605438
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2915.40
TSCA
Yes
RTECS
AF8575000

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