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3-Bromo-4-methylbenzoic acid has been used in the synthesis of biphenyl amides, 2-benzazepine-4-acetic acid derivative, as an analog of the potent, nonpeptide GPIIb/IIIa antagonist, O-spiro C-aryl glucosides. It is also used as catalytic agent and petrochemical additive.
Baihua Xu; Binhua Lv; Yan Feng; Ge Xu; Jiyan Du; Ajith Welihinda; Zelin Sheng; Brian Seed; Yuanwei Chen. O-SpiroC-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors. Bioorganic & Medicinal Chemistry Letters.2009, 19 (19), 5632-5635.
Richard M Angell; Tony D Angell; Paul Bamborough; David Brown; Murray Brown; Jacky B Buckton; Stuart G Cockerill; Chris D Edwards; Katherine L Jones; Tim Longstaff; Penny A Smee; Kathryn J Smith; Don O Somers; Ann L Walker; Malcolm Willson. Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR. Bioorganic & Medicinal Chemistry Letters.2008, 18 (1), 324-328.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P280g-P305+P351+P338
Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.