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A11498 Ethyl cyanoacetate, 98+%

CAS Number
105-56-6
Synonyms
Cyanoacetic acid ethyl ester

Stock No. Size Price ($) Quantity Availability
A11498-36 500g 44.90
A11498-0E 2500g 172.00
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Ethyl cyanoacetate, 98+%

MDL
MFCD00001940
EINECS
203-309-0

Chemical Properties

Formula
C5H7NO2
Formula Weight
113.12
Melting point
-23°
Boiling Point
208-210°
Flash Point
109°(228°F)
Density
1.063
Refractive Index
1.4180
Storage & Sensitivity
Ambient temperatures.
Solubility
It is slightly soluble in water. Mostly soluble in organic solvents such as chloroform, ethyl acetate.

Applications

Cyanoacetate is a building block for the synthesis of heterocycles and are are used as drugs. It is also used as Pharmaceutical intermediates, or Oil soluble couplers of film raw material . It is also used as a reagent in labelled pyrimidine and purine synthesis. It is used as an intermediate of fine chemicals such as medicine and dyestuff.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible materials strong acids, strong bases, strong oxidizing agents, strong reducing agents.

Literature References

Jose A. Cabello.; Juan M. Campelo.; Angel Garcia.; Diego Luna.; Jose M. Marinas. Knoevenagel condensation in the heterogeneous phase using aluminum phosphate-aluminum oxide as a new catalyst. J. Org. Chem. 1984, 49, (26), 5195-5197.

Rajendra K. Singh.; Samuel Danishefsky. Preparation of activated cyclopropanes by phase transfer alkylation. J. Org. Chem. 1975, 40, (20), 2969-2970.

Stereoselective alkylation of the active methylene has been accomplished under particularly mild conditions with secondary alkyl mesylates in the presence of CsF in DMF; complete inversion occurs at the secondary alkyl carbon: J. Org. Chem., 60, 2627 (1995).

Arylation by aryl iodides is promoted by copper(I) iodide: Synthesis, 67 (1983); J. Org. Chem., 58, 7606 (1993); or trans-Dichlorobis(triphenyl­phosphine)­palladium(II)­, 10491: Synthesis, 506 (1985).

For examples of Knoevenagel condensations of cyanoacetic esters with carbonyl compounds, see: Org. Synth. Coll., 3, 385, 399 (1955); 4, 93, 463 (1963); review: Org. React., 15, 204 (1967). Knoevenagel condensation with aromatic aldehydes has also been carried out under acidic conditions, for example, good yields have been obtained with ZnCl2: Tetrahedron Lett., 32, 5821 (1991).

For use in the synthesis of pyrrole derivatives, see p-Toluenesulfonyl­methyl­ isocyanide, A14312.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,3786
Beilstein
605871
Harmonized Tariff Code
2926.90
TSCA
Yes
RTECS
AG4110000

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