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p-Tolyl isothiocyanate has been used in the preparation of 6-[1-amino-3-(p-tolyl)-thiourea]-2-ethylbenzo[de]isoquinoline-1,3-dione. It is used as capping agent to cap the N-terminal ends of polypeptide. It is also used as pharmaceutical intermediate.
Thorfinnur Gunnlaugsson; Paul E Kruger; Paul Jensen; Juliann Tierney; Haslin Dato Paduka Ali; Gillian M Hussey. Colorimetric "naked eye" sensing of anions in aqueous solution. Journal of Organic Chemistry.2005, 70 (26), 10875-10878.
D H Swenson; K el-Bayoumy; G H Shuie; S S Hecht; E Fiala; F F Kadlubar; J P Freeman. Synthesis of N-(purin-8-yl)arylamines. Chemical Research in Toxicology.1993, 6 (4), 480-485.
Hazard Statements: H302-H312-H332-H314-H318
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.