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622-59-3 - p-Tolyl isothiocyanate, 97% - 4-Methylphenyl isothiocyanate - A11499 - Alfa Aesar

A11499 p-Tolyl isothiocyanate, 97%

CAS Number
622-59-3
Synonyms
4-Methylphenyl isothiocyanate

Size Price ($) Quantity Availability
5g 33.03
25g 98.17
100g 279.20
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p-Tolyl isothiocyanate, 97%

MDL
MFCD00004813
EINECS
210-745-5

Chemical Properties

Formula
C8H7NS
Formula Weight
149.22
Melting point
23-26°
Boiling Point
236-238°
Flash Point
107°(224°F)
Refractive Index
1.6345
Sensitivity
Moisture Sensitive
Solubility
Decompose in water.

Applications

p-Tolyl isothiocyanate has been used in the preparation of 6-[1-amino-3-(p-tolyl)-thiourea]-2-ethylbenzo[de]isoquinoline-1,3-dione. It is used as capping agent to cap the N-terminal ends of polypeptide. It is also used as pharmaceutical intermediate.

Notes

Moisture Sensitive. Protect from humidity and water. Store under dry inert gas away from oxidizing agents and moisture.

Literature References

Thorfinnur Gunnlaugsson; Paul E Kruger; Paul Jensen; Juliann Tierney; Haslin Dato Paduka Ali; Gillian M Hussey. Colorimetric "naked eye" sensing of anions in aqueous solution. Journal of Organic Chemistry.2005, 70 (26), 10875-10878.

D H Swenson; K el-Bayoumy; G H Shuie; S S Hecht; E Fiala; F F Kadlubar; J P Freeman. Synthesis of N-(purin-8-yl)arylamines. Chemical Research in Toxicology.1993, 6 (4), 480-485.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H302-H312-H332

Causes severe skin burns and eye damage. Causes serious eye damage. Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Precautionary Statements: P260-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
386032
Hazard Class
8
Packing Group
III
Harmonized Tariff Code
2930.90
TSCA
No
RTECS
NX9500000

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