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Guanine hydrochloride is one of the strongest denaturant. It is mainly used in protein purification and protein folding studies. It is a nucleobase used in biochemical research.
Sadleir, K. R.; Eimer, W. A.; Cole, S. L.; Vassar, R. A β reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Mol. Neurodegener. 2015, 10 (1), 1-16.
Sahoo, D. K.; Sahu, P. K. Stability-Indicating RP-HPLC Method for the Determination of Valaciclovir Hydrochloride in Bulk and Pharmaceutical Dosage Forms. Chem. Sci. Trans. 2014, 3 (2), 510-517.