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91-22-5 - Quinoline, 97% - A11545 - Alfa Aesar

A11545 Quinoline, 97%

CAS Number

Size Price ($) Quantity Availability
100g 34.30
500g 51.66
2500g 165.60
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Quinoline, 97%


Chemical Properties

Formula Weight
Melting point
Boiling Point
Flash Point
Refractive Index
Light Sensitive & Hygroscopic
More soluble in hot than cold water. Miscible with alcohol, ether


Quinoline is used as a chemical intermediate for making medicines and other organic compounds.  It acts as a fundamental structure in some antihypertensive agents such as prazosin and doxazosin which are peripheral vasodilator. It is also used in alkaloids, dyes, rubber chemicals and flavoring agents. They are also used as catalyst, corrosion inhibitor, preservative, and as solvent for resins and terpenes. They are used in transition-metal complex catalyst chemistry for uniform polymerization and luminescence chemistry. They are used as antifoaming agent in refinery field.


Dissolves sulfur, As{2}O{3}, phosphorus

Literature References

Khan KM.; Saify ZS.; Khan ZA.; Ahmed M.; Saeed M.; Schick M.; Kohlbau HJ.; Voelter W. Syntheses and cytotoxic, antimicrobial, antifungal and cardiovascular activity of new quinoline derivatives. Eur. pubmedcentral.200050, (10), 915-924].

Krzysztof R. Januszkiewicz.; Howard Alper. Exceedingly mild, selective and stereospecific phase-transfer-catalyzed hydrogenation of arenes. Organometallics. 1983, 2, (8), 1055-1057.

Reacts with acyl halides in the presence of an alkali cyanide to give Reissert compounds. For reviews, see: Chem. Rev., 55, 511 (1955); Adv. Het. Chem., 9, 1 (1968); 24, 187 (1979). See also Isoquinoline, B21279. For the formation of Reissert compounds under phase-transfer conditions, with a variety of carbonyl, sulfonyl and phosphoryl halides, see: Synthesis, 497 (1977). For 'direct' cyanation by a modified Reissert procedure, using DBU, see: J. Org. Chem., 49, 4056 (1984).

Dehydrohalogenation base; see, e.g.: Org. Synth. Coll., 4, 608 (1963).

Widely used solvent for the copper-promoted decarboxylation of carboxylic acids; see, e.g.: Org. Synth. Coll., 4, 731, 857 (1963).

Enhances selectivity of reduction of alkynes to alkenes over Lindlar catalyst: Org. Synth. Coll., 5, 880 (1973). In combination with sulfur, is a catalyst poison for the Rosenmund reduction of acid chlorides to aldehydes: Org. Synth. Coll., 3, 629 (1955), Note 4.

Li or Na in liquid ammonia give the 1,4-dihydro-derivative: Tetrahedron Lett., 2395 (1975), whereas pyridine-borane gives 1,2,3,4-tetrahydroquinoline: Synthesis, 447 (1978). Reaction with NaBH4 and a carboxylic acid results in "reduction-alkylation" to a 1-alkyl-1,2,3,4-tetrahydroquinoline: Synthesis, 650 (1975); compare also Sodium cyanoborohydride, 87839. However, selective hydrogenation of the benzene ring over PtO2 in conc. HCl was reported: J. Am. Chem. Soc., 96, 2256 (1974).

A novel radical alkylation of quinoline and related heterocycles in the 2-position uses free radicals generated by reaction of alkyl iodides with hydrogen peroxide in DMSO: J. Org. Chem., 54, 5224 (1989). For silver(II)-promoted radical alkylation, see: Trimethyl­acetic acid, A10776.

GHS Hazard and Precautionary Statements

Hazard Statements: H311-H302-H315-H319-H350-H341-H411-H401

Toxic in contact with skin. Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause cancer. Suspected of causing genetic defects. Toxic to aquatic life with long lasting effects. Toxic to aquatic life.

Precautionary Statements: P201-P273-P280-P281-P305+P351+P338-P361-P362-P301+P312-P405-P501a

Obtain special instructions before use. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Remove/Take off immediately all contaminated clothing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

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