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A11626 4,4'-Dimethoxytrityl chloride, 98%

CAS Number
40615-36-9
Synonyms
4,4'-Dimethoxytriphenylmethyl chloride
DMT

Stock No. Size Price ($) Quantity Availability
A11626-06 5g 42.20
A11626-14 25g 130.00
A11626-22 100g 442.00
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4,4'-Dimethoxytrityl chloride, 98%

MDL
MFCD00008409
EINECS
255-002-6

Chemical Properties

Formula
C21H19ClO2
Formula Weight
338.83
Melting point
121-127°
Storage & Sensitivity
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Solubility
Soluble in chloroform and methanol. Partially soluble in water

Applications

4,4'-Dimethoxytrityl chloride is used as a protective reagent for oligonucleotide synthesis. It is used for selective protection and deprotection procedures for thiol and hydroxy groups in nucleoside derivatives.

Notes

Moisture sensitive, hygroscopic. Incompatible with strong oxidizing agents.

Literature References

Ingale, S. A.; Leonard, P.; Tran, Q. N.; Seela, F. Duplex DNA and DNA-RNA Hybrids with Parallel Strand Orientation: 2'-Deoxy-2'-fluoroisocytidine, 2'-Deoxy-2'-fluoroisoguanosine, and Canonical Nucleosides with 2'-Fluoro Substituents Cause Unexpected Changes on the Double Helix Stability. J. Org. Chem. 2015, 80 (6), 3124-3138.

Vemekar, S. K. V.; Qiu, L.; Zhang, J.; Kankanala, J.; Li, H.; Geraghty, R. J.; Wang, Z. 5'-Silylated 3'-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus. J. Med. Chem. 2015, 58 (9), 4016-4028.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2471942
Harmonized Tariff Code
2909.30
TSCA
No

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