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372-48-5 - 2-Fluoropyridine, 99% - A11627 - Alfa Aesar

A11627 2-Fluoropyridine, 99%

CAS Number
372-48-5
Synonyms

Size Price ($) Quantity Availability
10g 29.61
25g 58.87
100g 193.64
250g 341.49
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2-Fluoropyridine, 99%

MDL
MFCD00006224
EINECS
206-757-5

Chemical Properties

Formula
C5H4FN
Formula Weight
97.09
Boiling Point
124-126°
Flash Point
24°(75°F)
Density
1.129
Refractive Index
1.4670
Solubility
Soluble in water.

Applications

2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.

Notes

Store in a cool, dry, well-ventilated area away from incompatible substances such as oxidizing agents.

Literature References

Lubov Pasumansky; Armando R. Hernández; Soya Gamsey; Christian T. Goralskib; Bakthan Singaram. Synthesis of aminopyridines from 2-fluoropyridine and lithium amides. Tetrahedron Letters.2004, 45 413-417.

The possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine makes 2-fluoropyridine a useful precursor of a wide range of 2,3-disubstituted pyridines. See, e.g.: J. Org. Chem., 53, 2740 (1988):

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P261-P280-P240-P303+P361+P353-P305+P351+P338-P304+P340-P362-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1515
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2933.39
TSCA
No
RTECS
UT3900000

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