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A11630 1-Bromo-4-fluorobenzene, 99%

CAS Number
460-00-4
Synonyms
4-Bromofluorobenzene

Stock No. Size Price ($) Quantity Availability
A11630-22 100g 44.90
A11630-36 500g 135.00
A11630-0E 2500g 530.00
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1-Bromo-4-fluorobenzene, 99%

MDL
MFCD00000342
EINECS
207-300-2

Chemical Properties

Formula
C6H4BrF
Formula Weight
175.01
Melting point
-16°
Boiling Point
151-153°
Flash Point
60°(140°F)
Density
1.604
Refractive Index
1.5270
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water(0.14g/L).

Applications

1-Bromo-4-fluorobenzene is used as an intermediate in the synthesis of atypical antipsychotic agents.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Xi-Bin Gu.; Guang-Jun Wang.; Jian-Hua Huang.; Ke-Li Han.; Guo-Zhong He.; Nan-Quan Lou. Photofragment Translational Spectroscopy of 1-Bromo-3-fluorobenzene and 1-Bromo-4-fluorobenzene at 266 nm. J. Phys. Chem. 2001, 105, (2), 354-362.

Kuniaki Kawataa.; Tsuyoshi Ibarakia.; Akiko Tanabea.; Hiroaki Yagoha.; Akiko Shinodab.; Hiroshi Suzukib.; Akio Yasuhara. Gas chromatographic-mass spectrometric determination of hydrophilic compounds in environmental water by solid-phase extraction with activated carbon fiber felt. Journal of Chromatography A. 2001, 911, (1), 75-83.

The Br undergoes selective displacement with Na alkoxides in NMP, in the presence of CuBr: Tetrahedron, 48, 3633 (1992).

Lithiation with LDA at -75o results mainly in deprotonation ortho to F; subsequent reaction with CO2 gives 5-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 33, 7495 (1992). Improved yields are obtained by the use of Li 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H312-H315-H319-H332-H335

Flammable liquid and vapour. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. Harmful if inhaled. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P261-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
774102
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2903.99
TSCA
Yes
RTECS
CY9033750

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