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460-00-4 - 1-Bromo-4-fluorobenzene, 99% - 4-Bromofluorobenzene - A11630 - Alfa Aesar

A11630 1-Bromo-4-fluorobenzene, 99%

CAS Number
460-00-4
Synonyms
4-Bromofluorobenzene

Size Price ($) Quantity Availability
100g 43.67
500g 130.81
2500g 515.00
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1-Bromo-4-fluorobenzene, 99%

MDL
MFCD00000342
EINECS
207-300-2

Chemical Properties

Formula
C6H4BrF
Formula Weight
175.01
Melting point
-16°
Boiling Point
151-153°
Flash Point
60°(140°F)
Density
1.604
Refractive Index
1.5270
Solubility
Soluble in water(0.14g/L).

Applications

1-Bromo-4-fluorobenzene is used as an intermediate in the synthesis of atypical antipsychotic agents.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Xi-Bin Gu.; Guang-Jun Wang.; Jian-Hua Huang.; Ke-Li Han.; Guo-Zhong He.; Nan-Quan Lou. Photofragment Translational Spectroscopy of 1-Bromo-3-fluorobenzene and 1-Bromo-4-fluorobenzene at 266 nm. J. Phys. Chem. 2001, 105, (2), 354-362.

Kuniaki Kawataa.; Tsuyoshi Ibarakia.; Akiko Tanabea.; Hiroaki Yagoha.; Akiko Shinodab.; Hiroshi Suzukib.; Akio Yasuhara. Gas chromatographic-mass spectrometric determination of hydrophilic compounds in environmental water by solid-phase extraction with activated carbon fiber felt. Journal of Chromatography A. 2001, 911, (1), 75-83.

The Br undergoes selective displacement with Na alkoxides in NMP, in the presence of CuBr: Tetrahedron, 48, 3633 (1992).

Lithiation with LDA at -75o results mainly in deprotonation ortho to F; subsequent reaction with CO2 gives 5-bromo-2-fluorobenzoic acid: Tetrahedron Lett., 33, 7495 (1992). Improved yields are obtained by the use of Li 2,2,6,6-tetramethylpiperidide (LTMP) as base: Tetrahedron Lett., 37, 6551 (1996).

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H332-H319-H313

Flammable liquid and vapour. Harmful if inhaled. Causes serious eye irritation. May be harmful in contact with skin.

Precautionary Statements: P261-P305+P351+P338

Avoid breathing dust/fume/gas/mist/vapours/spray. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Beilstein
774102
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2903.99
TSCA
Yes
RTECS
CY9033750

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