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A11668 Semicarbazide hydrochloride, 99%

CAS Number
563-41-7
Synonyms

Stock No. Size Price ($) Quantity Availability
A11668-22 100g 24.10
A11668-36 500g 69.20
A11668-0E 2500g 271.00
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Semicarbazide hydrochloride, 99%

MDL
MFCD00013009
EINECS
209-247-0

Chemical Properties

Formula
CH4N3O•HCl
Formula Weight
111.53
Melting point
ca 176° dec.
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water (>100g/L).

Applications

Semicarbazide hydrochloride is used as urease substrate and MAO inhibitor. Derivatizing agent for carbonyl compounds as their semicarbazones which produces crystalline compounds with characteristic melting points. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid.

Notes

Store in cool, dry conditions in well sealed container. Store away from oxidizing agent.

Literature References

Phedias Diamandis et. al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology. 2007, 3 (5), 268-273.

Fumiko Marttila-Ichihara; Karolien Castermans; Kaisa Auvinen; Mirjam G A Oude Egbrink; Sirpa Jalkanen; Arjan W Griffioen; Marko Salmi. Small-molecule inhibitors of vascular adhesion protein-1 reduce the accumulation of myeloid cells into tumors and attenuate tumor growth in mice. Journal of Immunology. 2010, 184 (6), 3164-3173.

Derivatizing agent for carbonyl compounds as their semicarbazones. Also used in heterocyclic synthesis. Semicarbazone formation has been used to separate carbonyl compounds from mixtures by adsorption onto silica gel from a hydrocarbon solution. Regeneration is by hydrolysis with oxalic acid: Tetrahedron, 37, 843 (1981).

Other reagents for the cleavage of semicarbazones include: Amberlyst® 15 in aqueous acetone: J .Chem. Soc., Perkin 1, 2563 (1988); Dowex® 50 in aqueous suspension: J. Org. Chem., 53, 878 (1988); CuSO4 in aqueous THF: J. Prakt. Chem., 322 1063 (1980).

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H351

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. Suspected of causing cancer.

Precautionary Statements: P201-P202-P264b-P270-P280-P280i-P301+P310-P302+P352-P305+P351+P338-P308+P313-P310-P330-P332+P313-P362-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. Wear eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,8444
Beilstein
3593642
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2928.00
TSCA
Yes
RTECS
VT3500000

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