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694-80-4 - 1-Bromo-2-chlorobenzene, 98+% - 2-Bromochlorobenzene - A11782 - Alfa Aesar

A11782 1-Bromo-2-chlorobenzene, 98+%

CAS Number
694-80-4
Synonyms
2-Bromochlorobenzene

Size Price ($) Quantity Availability
50g 47.52
250g 140.00
1000g 460.80
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1-Bromo-2-chlorobenzene, 98+%

MDL
MFCD00000532
EINECS
211-775-1

Chemical Properties

Formula
C6H4BrCl
Formula Weight
191.46
Melting point
-13°
Boiling Point
203-205°
Flash Point
79°(174°F)
Density
1.649
Refractive Index
1.5815
Solubility
Immiscible with water.

Applications

1-Bromo-2-chlorobenzene finds application in Gas Chromatography and Liquid Chromatography analysis. It is also used as an intermediate in pharmaceutical and synthetic chemistry. Further, it acts as a reagent in the preparation of arylpiperidines and aryltetrahydropyridines as 5-HT<sub>2C</sub> agonists.

Notes

Store in a cool place. Incompatible with strong oxidizing agents.

Literature References

Lithiation with LDA occurs ortho to the chlorine atom; subsequent reaction with electrophiles provides access to mixed dihalo derivatives such as 3-bromo-2-chlorobenzoic acid: Tetrahedron Lett., 36, 881 (1995).

Chen, J.; Natte, K.; Wu, X. F. Convenient palladium-catalyzed carbonylative synthesis of caprolactam and butyrolactam derived phthalimides and amides by using DBU and DBN as the nitrogen source. Tetrahedron Lett. 2015, 56 (2), 342-345.

Gao, J.; Zhu, J.; Chen, L.; Shao, Y.; Zhu, J.; Huang, Y.; Wang, X.; Lv, X. Synthesis of benzimidazo[2,1-b]benzothiazole derivatives through sequential Cu-catalyzed domino coupling and Pd-catalyzed Suzuki reaction. Tetrahedron Lett. 2014, 55 (22), 3367-3373.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Precautionary Statements: P280g-P305+P351+P338

Wear protective gloves. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Other References

Beilstein
1855303
Harmonized Tariff Code
2903.99
TSCA
Yes

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