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707-61-9 - 3-Methyl-1-phenyl-2-phospholene 1-oxide, 94% - A11792 - Alfa Aesar

A11792 3-Methyl-1-phenyl-2-phospholene 1-oxide, 94%

CAS Number
707-61-9
Synonyms

Size Price ($) Quantity Availability
5g 57.89
25g 206.00
100g 533.60
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3-Methyl-1-phenyl-2-phospholene 1-oxide, 94%

MDL
MFCD00014518
EINECS
211-901-5

Chemical Properties

Formula
C11H13OP
Formula Weight
192.19
Melting point
60-65°
Boiling Point
173-174°/0.7mm
Sensitivity
Hygroscopic
Solubility
Soluble in polar solvents.

Applications

3-Methyl-1-phenyl-2-phospholene 1-oxide is used as a catalyst for intramolecular aza-wittig cyclization reactions and polymerization reactions. It is a reactant used for the preparation of phospha sugars and their radical bromination derivatives as anticancer agents.

Notes

Hygroscopic. Incompatible with strong oxidizing agents.

Literature References

(previously believed to have the double bond in the 3-position)

Catalyst for conversion of isocyanates to carbodiimides: Org. Synth. Coll., 5, 501 (1973).

Makita, R.; Yamashita, M.; Yamaoka, M.; Fuije, M.; Nakamura, S.; Oshikawa, T.; Yamashita, J.; Yamada, M.; Asai, K.; Suyama, T.; Kondo, M.; Hasegawa, H.; Okita, Y.; Hirakawa, K.; Toda, M.; Ohnishi, K.; Sugimura, H. Novel Multiple Type Molecular Targeted Antitumor Agents: Preparation and Preclinical Evaluation of Low-Molecular-Weight Phospha Sugar Derivatives. Phosphorus Sulfur 2015, 190 (5-6), 733-740.

Hu, G.; Gao, Y.; Zhao, Y. Copper-Catalyzed Decarboxylative C-P Cross-Coupling of Alkynyl Acids with H-Phosphine Oxides: A Facile and Selective Synthesis of (E)-1-Alkenylphosphine Oxides. Org. Lett. 2015, 16 (17), 4464-4467.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264-P270-P301+P312-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
609223
Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
SZ6105100

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