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A11792 3-Methyl-1-phenyl-2-phospholene 1-oxide, 94%

CAS Number
707-61-9
Synonyms

Stock No. Size Price ($) Quantity Availability
A11792-06 5g 60.20
A11792-14 25g 212.00
A11792-22 100g 715.00
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3-Methyl-1-phenyl-2-phospholene 1-oxide, 94%

MDL
MFCD00014518
EINECS
211-901-5

Chemical Properties

Formula
C11H13OP
Formula Weight
192.19
Melting point
60-65°
Boiling Point
173-174°/0.7mm
Storage & Sensitivity
Hygroscopic. Store under Argon. Ambient temperatures.
Solubility
Soluble in polar solvents.

Applications

3-Methyl-1-phenyl-2-phospholene 1-oxide is used as a catalyst for intramolecular aza-wittig cyclization reactions and polymerization reactions. It is a reactant used for the preparation of phospha sugars and their radical bromination derivatives as anticancer agents.

Notes

Hygroscopic. Incompatible with strong oxidizing agents.

Literature References

(previously believed to have the double bond in the 3-position)

Catalyst for conversion of isocyanates to carbodiimides: Org. Synth. Coll., 5, 501 (1973).

Makita, R.; Yamashita, M.; Yamaoka, M.; Fuije, M.; Nakamura, S.; Oshikawa, T.; Yamashita, J.; Yamada, M.; Asai, K.; Suyama, T.; Kondo, M.; Hasegawa, H.; Okita, Y.; Hirakawa, K.; Toda, M.; Ohnishi, K.; Sugimura, H. Novel Multiple Type Molecular Targeted Antitumor Agents: Preparation and Preclinical Evaluation of Low-Molecular-Weight Phospha Sugar Derivatives. Phosphorus Sulfur 2015, 190 (5-6), 733-740.

Hu, G.; Gao, Y.; Zhao, Y. Copper-Catalyzed Decarboxylative C-P Cross-Coupling of Alkynyl Acids with H-Phosphine Oxides: A Facile and Selective Synthesis of (E)-1-Alkenylphosphine Oxides. Org. Lett. 2015, 16 (17), 4464-4467.

Other References

Beilstein
609223
Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
SZ6105100

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