Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

A11801 N-Ethyldiisopropylamine, 99%

CAS Number
7087-68-5
Synonyms
DIEA
N,N-Diisopropylethylamine

Stock No. Size Price ($) Quantity Availability
A11801-AE 100ml 34.90
A11801-AP 500ml 116.00
A11801-0F 2500ml 411.00
Add to Cart Bulk/Specialty Print Quote View Item

N-Ethyldiisopropylamine, 99%

MDL
MFCD00008868
EINECS
230-392-0

Chemical Properties

Formula
C8H19N
Formula Weight
129.25
Melting point
-46°
Boiling Point
126-127°
Flash Point
8°(46°F)
Density
0.747
Refractive Index
1.4135
Storage & Sensitivity
Ambient temperatures.
Solubility
Miscible with water and ethanol.

Applications

N-Ethyldiisopropylamine is used to make or formulate industrial products. It is also used in organic chemistry as a base. It acts as a selective reagent in the alkylation of secondary amines to tertiary amines by alkyl halides. It reacts with monoactivated Michael acceptors to afford symmetrical sulfones. Further, it is used to prepare heterocyclic compound, sscorpionine by a reaction with disulfur dichloride using 1,4-diazabicyclo[2.2.2]octane (DABCO) as a catalyst.

Notes

Incompatible with acids, acid chlorides, acid anhydrides, carbon dioxide, copper, brass, rubber, oxidizing agents, nitrates, peroxides, aldehydes and metals.

Literature References

Hindered non-nucleophilic base with high proton affinity: Chem. Ber., 91, 380 (1958).

For use in the introduction of TBDMS protecting groups, see tert-Butyl­dimethyl­chlorosilane, A13064 . Used in preparation of silyl enol ethers from both aldehydes and ketones: Helv. Chim. Acta, 60, 181 (1977).

Useful base in peptide coupling reactions: J. Am. Chem. Soc., 91, 6488 (1969). See Appendix 6.

Has been recommended as a base for the Horner-Wadsworth-Emmons olefination reaction, where the reagents contain groups sensitive to base-catalyzed epimerization or condensation. The reaction is carried out in the presence of LiCl, and gives high (E):(Z) ratios: Tetrahedron Lett., 25, 2183 (1984).

Vembu, S.; Pazhamalai, S.; Gopalakrishnan, M. Potential antibacterial activity of triazine dendrimer: Synthesis and controllable drug release properties. Bioorg. Med. Chem. 2015, 23 (15), 4561-4566.

Manandhar, Y.; Bahadur, K. C. T.; Wang, W.; Uzawa, T.; Aigaki, T.; Ito, Y. In vitro selection of a peptide aptamer that changes fluorescence in response to verotoxin. Biotechnol. Lett 2015, 37 (3), 619-625.

GHS Hazard and Precautionary Statements

Hazard Statements: H225-H290-H302-H318-H331-H335

Highly flammable liquid and vapour. May be corrosive to metals. Harmful if swallowed. Causes serious eye damage. Toxic if inhaled. May cause respiratory irritation.

Precautionary Statements: P210-P233-P234-P235-P240-P241-P242-P243-P261-P264b-P270-P271-P280-P301+P312-P303+P361+P353-P304+P340-P305+P351+P338-P310-P311-P330-P370+P378q-P390-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep only in original container. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician. Rinse mouth. In case of fire: Use CO2, dry chemical, or foam Absorb spillage to prevent material damage. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
605301
Hazard Class
6.1
Packing Group
I
Harmonized Tariff Code
2921.19
TSCA
Yes

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware