Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

A11824 4-Bromoanisole, 99%

CAS Number
104-92-7
Synonyms
4-Methoxybromobenzene

Stock No. Size Price ($) Quantity Availability
A11824-22 100g 33.50
A11824-36 500g 114.00
A11824-0E 2500g 465.00
Add to Cart Bulk/Specialty Print Quote View Item

4-Bromoanisole, 99%

MDL
MFCD00000097
EINECS
203-252-1

Chemical Properties

Formula
C7H7BrO
Formula Weight
187.04
Melting point
10-13°
Boiling Point
98-99°/10mm
Flash Point
94°(201°F)
Density
1.494
Refractive Index
1.5640
Storage & Sensitivity
Ambient temperatures.
Solubility
Immiscible with water.

Applications

4-Bromoanisole finds application as an intermediate in synthetic chemistry. It is used in the preparation of aryl 1,3-diketones and ethyl 4-methoxycinnamate. It is a used as a brominating reagent. Further, it is used in Suzuki coupling reaction with phenylboronic acid as well as in Heck reaction.

Notes

Incompatible with strong oxidizing agents and strong acids.

Literature References

Nucleophilic displacement of Br can be effected with Na alkoxides in NMP in the presence of CuBr: Tetrahedron, 48, 3633 (1992).

For formation of the Grignard, conversion to the stannane and Stille coupling with an aryl triflate, catalyzed by trans-Dichlorobis(triphenyl­phosphine)­palladium(II)­, 10491, see: Org. Synth. Coll., 9, 553 (1998).

Moore, J. N.; Laskay, N. M.; Duque, K. S.; Kelley, S. P.; Rogers, R. D.; Shaughnessy, K. H. Synthesis of 4-sulfonatobenzylphosphines and their application in aqueous-phase palladium-catalyzed cross-coupling. J. Organomet. Chem. 2015, 777, 16-24.

Semmes, J. G.; Bevans, S. L.; Mullins, C. H.; Shaughnessy, K. H. Arylation of diethyl malonate and ethyl cyanoacetate catalyzed by palladium/di-tert-butylneopentylphosphine. Tetrahedron Lett. 2015, 56 (23), 3447-3450.

Hazard Statements:

May be harmful if swallowed.

Precautionary Statements:

Call a POISON CENTER/doctor if you feel unwell.

Other References

Merck
14,1427
Beilstein
1237590
Harmonized Tariff Code
2909.30
TSCA
Yes
RTECS
BZ8501000

Recommended

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware