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Hexamethyldisiloxane is used as a solvent in organic reactions. It finds application as an international standard for 1H NMR spectroscopy for calibrating chemical shift. Further, it is used in liquid bandages to protect skin from irritation. In addition, it is used to measure tissue oxygen tension as a receptor molecule. It is also used to make low-k dielectric materials for the semi-conductor industries by plasma-enhanced chemical vapor deposition(PECVD) method.
Silylates primary and sec-alcohols and phenols, in the presence of p-TsOH as catalyst. If the substrate contains acid-sensitive groups, PPTS can be used: Tetrahedron Lett., 4261 (1978). See Appendix 4.
In the presence of FeCl3, reacts with benzotrichlorides to give substituted benzoyl chlorides in good yields: J. Chem. Soc., Chem. Commun., 808 (1977).
Reacts with P2O5 to give trimethylsilyl polyphosphate ('PPSE'), a milder and more convenient dehydrating agent then polyphosphoric acid. For examples, and related reagents, see Phosphorus(V) oxide, A13348.
Bashir, M.; Bashir, S. Hydrophobic-Hydrophilic Character of Hexamethyldisiloxane Films Polymerized by Atmospheric Pressure Plasma Jet. Plasma Chem. Plasma Process 2015, 35 (4), 739-755.
Hsiao, C. R.; Lin, C. W.; Chou, C. M.; Chung, C. J.; He, J. L. Surface modification of blood-contacting biomaterials by plasma-polymerized superhydrophobic films using hexamethyldisiloxane and tetrafluoromethane as precursors. Appl. Surf. Sci. 2015, 346, 50-56.
Hazard Statements: H225
Highly flammable liquid and vapour.
Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P260-P271-P280-P303+P361+P353-P304+P340-P312-P314-P370+P378q-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician if you feel unwell. Get medical advice/attention if you feel unwell. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant