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Bromoform is widely used as a solvent for waxes, oils and greases. It is utilized for mineral ore separation in geological tests. It is used as an intermediate in chemical synthesis as well as a laboratory reagent. It is the ingredient of fire-resistant chemicals and fluid gauges. It acts as a sedative and as cough reducing agent.
For examples of the generation of dibromocarbene, using Potassium tert-butoxide, A13947, as base, see: Org. Synth. Coll., 6, 187 (1988); 7, 200 (1990). Alternatively, reactions can be carried out with aqueous OH- and a phase-transfer catalyst such as Benzyltriethylammonium chloride, A13268: Org. Synth. Coll., 8, 223 (1993), or using crown ether catalysis: Org. Synth., 75, 98 (1997).
Under phase-transfer conditions, allylic bromides undergo nucleophilic displacement by the tribromomethyl anion: J. Chem. Soc., Chem. Commun., 210 (1979).
Wang, L.; Liu, P.; Zhang, S. Debromination and decomposition of bromoform by contact glow discharge electrolysis in an aqueous solution. Electrochim. Acta 2015, 165, 390-395.
Liu, B.; Li, X. F.; Zhang, J.; Wang, M. T.; Zeng, R. J. Synthesis of novel spiro[cyclopropane-pyrrolizin] derivatives via Mg-mediated conjugate addition of bromoform. Res. Chem. Intermed. 2015, 41 (4), 2345-2352.
Hazard Statements: H302-H315-H319-H331
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Toxic if inhaled.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P311-P330-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant