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N-Ethylmorpholine is a component of the buffer used in basic peptide separation through anion-exchange chromatography. Further, it acts as a catalyst in the preparation of polyurethane foam.
Base for use in peptide and similar coupling reactions. For example, has been used in conjunction with ethyl chloroformate for the mild coupling of substituted aromatic acids with primary amines or for the coupling of N-hydroxysuccinimide active esters with peptide residues: J. Med. Chem., 34, 2328 (1991). Compare 4-Methylmorpholine, A12158. For peptide reagents, see Appendix 6.
Shen, C.; Wang, P.; Beves, J. E. New ruthenium(II) complexes of 2, 2': 6', 2?-terpyridine derivatives as supramolecular building blocks. Polyhedron 2016, 103, 241-247.
Samide, M. J.; Smith, G. D. Analysis and quantitation of volatile organic compounds emitted from plastics used in museum construction by evolved gas analysis-gas chromatography-mass spectrometry. J. Chromatogr. A 2015, 1426, 201-208.
Hazard Statements: H226-H302-H311-H332-H314-H318
Flammable liquid and vapour. Harmful if swallowed. Toxic in contact with skin. Harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.