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Chloroacetone was used in the synthesis of double-chain nonionic surfactants with an acid decomposition function via acid-catalyzed condensation with fatty alcohols (octyl, decyl and dodecyl). It was also used in the synthesis of meso-tetramethyl tetrakis-(4-phenoxy acetone)calixpyrrole. It can also be used to make dye couplers for color photography and used in the Feist-Benary synthesis of furans.
Weijers CAGM, et al. Synthesis of optically pure 1, 2-epoxypropane by microbial asymmetric reduction of chloroacetone. Appl. Microbiol. Biotechnol.1992,38(3), 297-300.
He L, et al. L-Proline amide-catalyzed direct asymmetric aldol reaction of aldehydes with chloroacetone. Tetrahedron,2006, 62(2), 590-599.
Hazard Statements: H226-H301-H310-H330-H314-H318
Flammable liquid and vapour. Toxic if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P273-P280-P305+P351+P338-P309-P310a-P501a
Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or if you feel unwell: Immediately call a POISON CENTER/doctor Dispose of contents/container in accordance with local/regional/national/international regulations.