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2,6-dimethylphenol is used in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. In addition, this compound is used as a reactant in the synthesis of polyphenylene ether polymers.
Yasar Thewalim; Fredrik Aldaeus; Anders Colmsjö. Retention time prediction of compounds in Grob standard mixture for apolar capillary columns in temperature-programmed gas chromatography. Analytical and Bioanalytical Chemistry.2009,393(1), 327-334.
Masahiro Ogata et. al. Antioxidant activity of propofol and related monomeric and dimeric compounds. Chemical & Pharmaceutical Bulletin,2005, 53(3), 344-346.
O-Alkylation of this hindered phenol by alkyl halides has been achieved using NaOH with micellar catalysis by (1-Hexadecyl)trimethylammonium bromide, A15235: Tetrahedron, 44, 6677 (1988). Alkylation of the Li salt with MeI occurs preferentially on carbon to give the dimer of 2,6,6-trimethyl-2,4-cyclohexadienone: Org. Synth. Coll., 5, 1092 (1973).
Addition of lithiated 2,6-dimethylphenyl esters of alkanoic acids to carbonyl compounds has been used in a highly diastereoselective synthesis of ß-hydroxy acids. In some cases, only one of the two possible diastereomers is formed. For list of examples, see: Org. Synth. Coll., 7, 190 (1990).
Hazard Statements: H301-H311-H314
Toxic if swallowed. Toxic in contact with skin. Causes severe skin burns and eye damage.
Precautionary Statements: P260-P264b-P270-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant