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It is employed as an intermediate in the preparation of the muscle relaxant papverin. 3,4-Dimethoxyphenyl)acetonitrile has been used in the synthesis of (Z)-3-(benzo[b]thiophen-2-yl)-2-(3,4-dimethoxyphenyl)acrylonitrile1. It has also been used in the preparation of modified diterpene (±) nimbidiol which relies on a sulfenium ion promoted polyene cyclization.
Eide-Dittmar Luebs.; Alberto Cohen.; Edward J. Zaleski.; Richard J. Bing. Effect of nitroglycerin, intensain, isoptin and papaverine on coronary blood flow in man ?: Measured by the coincidence counting technic and rubidium. The American Journal of Cardiology. 1966, 17 (4),535-541.
A. Carpy, J.-M. Léger.; C. Melchiorre. Structure of [alpha]-isopropyl-[alpha]-[(N-methyl-N-homoveratryl)-[gamma]-aminopropyl]-3,4-dimethoxyphenylacetonitrile hydrochloride, verapamil, C27H38N2O4.HCl. Acta Cryst. 1985, (C41),624-627.
Reaction with dimethylamine in the presence of CuCl gives the N,N-dimethylamidine, which, on borohydride reduction, provides an efficient route to the N,N-dimethylphenethylamine: Tetrahedron Lett., 34, 6395 (1993); Org. Synth., 76, 133 (1998). The method is applicable to other alkyl nitriles and to both primary and secondary amines, providing a general route to secondary and tertiary amines from the corresponding nitriles:
Hazard Statements: H301-H311-H331
Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P311-P312-P330-P361-P363-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant