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352-34-1 - 1-Fluoro-4-iodobenzene, 99% - 4-Fluoroiodobenzene - A12008 - Alfa Aesar

A12008 1-Fluoro-4-iodobenzene, 99%

CAS Number
352-34-1
Synonyms
4-Fluoroiodobenzene

Size Price ($) Quantity Availability
10g 24.10
50g 115.36
250g 374.40
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1-Fluoro-4-iodobenzene, 99%

MDL
MFCD00001052
EINECS
206-522-7

Chemical Properties

Formula
C6H4FI
Formula Weight
222.00
Melting point
-20°
Boiling Point
182-184°
Flash Point
68°(154°F)
Density
1.925
Refractive Index
1.5830
Sensitivity
Light Sensitive
Solubility
Insoluble in water.

Applications

4-Fluoroiodobenzene was used in the preparation of fluorotriphenylene derivatives. 4-[F] Fluoroiodobenzene is a versatile building block in 18F radiochemistry and is used in various transition metal-mediated C-C and C-N cross-coupling reactions.

Notes

Light Sensitive. Store in cool dry place. Keep container tightly sealed.

Literature References

Jerry M. Meyersa.; Andrew J. Gellman. Effect of substituents on the phenyl coupling reaction on Cu(111).Surface Science. 1995, 337 (1-2), 40-50.

Hülya Akgün.; Tomas Hudlicky. Total syntheses of ert-conduramine A and ent-7-deoxypancratistatin. Tetrahedron Lett. 1999, 40 (16),3081-3084.

Regioselective metallation can be accomplished with LDA ortho to the fluoro substituent: Tetrahedron Lett., 33, 7499 (1992). Subsequent carboxylation and F - displacement with an amine has been used to synthesize 5-iodoanthranilic acid derivatives: J. Med. Chem., 40, 717 (1997).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Precautionary Statements: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1853970
Harmonized Tariff Code
2903.99
TSCA
Yes

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