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17564-64-6 - N-(Chloromethyl)phthalimide, 97% - A12018 - Alfa Aesar

A12018 N-(Chloromethyl)phthalimide, 97%

CAS Number

Size Price ($) Quantity Availability
25g 59.12
100g 182.30
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N-(Chloromethyl)phthalimide, 97%


Chemical Properties

Formula Weight
Melting point
Insoluble in water.


It is used as an agrochemical and medicine intermediates and is used in organic synthesis. Microporous membranes prepared from chemically modified polysulfone, which is a derivative of this compound have better streaming potential.


Store in cool place. Keep away from oxidizing agents. Incompatible with bases.

Literature References

Ekkehard Hinke.; Eberhard Staude. Streaming potential of microporous membranes made from homogeneously functionalized polysulfone. J. Appl. Polym. Sci. 1991, 42 (11),2951-2958.

M. Hariharan.; S. Chaberek.; A. E. Martella. Synthesis of Phosphonopeptide Derivatives. Synth. Commun. 1973, 3 (5),375-379.

Reagent for carboxyl protection, e.g. in peptide synthesis, by reaction in the presence of an amine: Rec. Trav. Chim., 82, 941 (1963); or with KF in DMF: Synth. Commun., 8, 515 (1978). The phthalimidomethyl ester can be cleaved in various ways including hydrazinolysis, HBr in acetic acid or Zn/AcOH. See also N-(Hydroxymethyl)­phthalimide, B21292 and Appendix 6.

Also reported for the protection of thiols as the S-phthalimidomethyl (Pim) derivative. Cleavage is by hydrazinolysis, followed by Hg(II), Cu(II) or I2: Chem. Lett., 2139 (1994).

Reagent for the amidomethylation of aromatic systems. For reviews of amidomethylation, see: Org. React., 14, 52 (1965); Synthesis, 49 (1970); 85, 181 (1984).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

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