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Employed as a nucleobase incorporated into biological nucleic acids. Guanine is suitable reagent used to investigate the mechanism of electrochemical oxidation of guanine and adenine using a glassy carbon microelectrode and cyclic and differential pulse voltammetry. It may be used in the preparation of mixed-sequence peptide nucleic acid (PNA) monomers.
A M Oliveira-Brett.; V Diculescu.; J A P Piedade. Electrochemical oxidation mechanism of guanine and adenine using a glassy carbon microelectrode.Bioelectrochemistry,2002,55(1-2), 61-62.
K Phillips.; Z Dauter.; A I Murchie.; D M Lilley.; B Luisi. The crystal structure of a parallel-stranded guanine tetraplex at 0.95 A resolution.J Mol Biol.1997,273(1), 171-182.
Dueholm KL, et al. Synthesis of peptide nucleic acid monomers containing the four natural nucleobases: thymine, cytosine, adenine, and guanine and their oligomerization.J. Org. Chem.1994,59(19), 5767-5773.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant