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2-Aminothiazole is used in the synthesis of 2-aminothiazole-modified silica gel and also used in Ulmann coupling with 2-chlorobenzoic acids mediated by ultrasonic irradiation. It acts as a component of disperse dye, thyroid inhibitor in the treatment of hyperthyroidism, as the acid tartrate and as a therapeutic drug for prion diseases. It is also used to kill bacteria.
Yadav, P.; Dutta, P. K.; Ballabh, A. Combinatorial Library Approach to Realize 2-Aminothiazole-Based Two-Component Hydrogelator: A Structure-Property Correlation.Cryst. Growth Des. 2014, 14 (11), 5966-5975.
Xiong, C.; Zhou, S.; Liu, X.; Jia, Q.; Ma, C.; Zheng, X. 2-Aminothiazole Functionalized Polystyrene for Selective Removal of Au(III) in Aqueous Solutions. Ind. Eng. Chem. Res. 2014, 53 (6), 2441-2448.
Xiong, C.; Jia, Q.; Chen, X.; Wang, G.; Yao, C. Optimization of Polyacrylonitrile-2-aminothiazole Resin Synthesis, Characterization, and Its Adsorption Performance and Mechanism for Removal of Hg(II) from Aqueous Solutions. Ind. Eng. Chem. Res. 2013, 52 (14), 4978-4986.
Giles, K.; Berry, D. B.; Condello, C.; Hawley, R. C.; Gallardo-Godoy, A.; Bryant, C.; Oehler, A.; Elepano, M.; Bhardwaj, S.; Patel, S.; Silber, M.; Guan, S.; Armond, S. J.; Renslo, A. R.; Prusiner, S. B. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J. Pharmacol. Exp. Ther. 2015, 355 (1), 2-12.
Hazard Statements: H302-H319-H335
Harmful if swallowed. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280i-P301+P312-P304+P340-P305+P351+P338-P312-P330-P337+P313-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear eye/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If eye irritation persists: Get medical advice/attention. Dispose of contents/ container to an approved waste disposal plant