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N,O-Bis(trimethylsilyl)trifluoroacetamide is used as a derivatization reagent for gas chromatography and mass-spectrometry analysis of phenolic acids in fruits. It is also used as a reactant in the preparation of pyrimidinone ribosides and analogs which shows anti-tumor properties. It plays as an important role as a reagent for the regioselective desulfation of polysaccharide sulfates. Furthermore, it is used to prepare trimethylsilyl ethers of carbohydrates and alcohols.
Powerful silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions, similar to N,O-Bis(trimethylsilyl)acetamide, L00183, with the advantage that both the reagent and its by-product, trifluoroacetamide, are more volatile than the corresponding non-fluorinated analogues: Biochem. Biophys. Res. Commun., 31, 616 (1968). See Appendix 4.
Sagona, J. A.; Dukett, J. E.; Hawley, H. A.; Mazurek, M. A. Sequential derivatization of polar organic compounds in cloud water using O-(2, 3, 4, 5, 6-pentafluorobenzyl) hydroxylamine hydrochloride, N, O-bis (trimethylsilyl) trifluoroacetamide, and gas-chromatography/mass spectrometry analysis. J. Chromatogr. A 2014, 1362, 16-24.
Irei, S.; Rudolph, J.; Huang, L. Compound-specific stable carbon isotope ratios of phenols and nitrophenols derivatized with N, O-bis (trimethylsilyl) trifluoroacetamide. Anal. Chim. Acta 2013, 786, 95-102.
Hazard Statements: H226-H314-H318
Flammable liquid and vapour. Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.