Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

A12033 N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+%

CAS Number
25561-30-2
Synonyms
BSTFA

Stock No. Size Price ($) Quantity Availability
A12033-09 10g 41.40
A12033-18 50g 142.00
A12033-22 100g 287.00
A12033-30 250g 589.00
Add to Cart Bulk/Specialty Print Quote View Item

N,O-Bis(trimethylsilyl)trifluoroacetamide, 98+%

MDL
MFCD00008269
EINECS
247-103-9

Chemical Properties

Formula
C8H18F3NOSi2
Formula Weight
257.40
Melting point
-10°
Boiling Point
145-147°
Flash Point
23°(73°F)
Density
0.97
Refractive Index
1.3840
Storage & Sensitivity
Keep Cold. Moisture Sensitive. Store under Nitrogen.
Solubility
Miscible with chloroform.

Applications

N,O-Bis(trimethylsilyl)trifluoroacetamide is used as a derivatization reagent for gas chromatography and mass-spectrometry analysis of phenolic acids in fruits. It is also used as a reactant in the preparation of pyrimidinone ribosides and analogs which shows anti-tumor properties. It plays as an important role as a reagent for the regioselective desulfation of polysaccharide sulfates. Furthermore, it is used to prepare trimethylsilyl ethers of carbohydrates and alcohols.

Notes

Moisture sensitive. Store in cool place. Keep the container tightly closed in a dry and well-ventilated place Incompatible with strong oxidizing agents and strong acids.

Literature References

Powerful silylation reagent useful in GC and GC-MS for the derivatization of a wide range of functional groups under mild conditions, similar to N,O-Bis(trimethyl­silyl)­acetamide, L00183, with the advantage that both the reagent and its by-product, trifluoroacetamide, are more volatile than the corresponding non-fluorinated analogues: Biochem. Biophys. Res. Commun., 31, 616 (1968). See Appendix 4.

Sagona, J. A.; Dukett, J. E.; Hawley, H. A.; Mazurek, M. A. Sequential derivatization of polar organic compounds in cloud water using O-(2, 3, 4, 5, 6-pentafluorobenzyl) hydroxylamine hydrochloride, N, O-bis (trimethylsilyl) trifluoroacetamide, and gas-chromatography/mass spectrometry analysis. J. Chromatogr. A 2014, 1362, 16-24.

Irei, S.; Rudolph, J.; Huang, L. Compound-specific stable carbon isotope ratios of phenols and nitrophenols derivatized with N, O-bis (trimethylsilyl) trifluoroacetamide. Anal. Chim. Acta 2013, 786, 95-102.

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H314-H335

Flammable liquid and vapour. Causes severe skin burns and eye damage. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
3607620
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2931.90
TSCA
No

Recommended

  • A12512

    1-(Trimethylsilyl)imidazole, 97%
  • A13141

    N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 97%
  • A13651

    Chlorotrimethylsilane, 98%
  • L04295

    Acetic anhydride, 99+%
  • 41547

    1-Methoxy-2-propanol, 99+%

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware