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92-43-3 - 1-Phenyl-3-pyrazolidinone, 97% - Phenidone - A12089 - Alfa Aesar

A12089 1-Phenyl-3-pyrazolidinone, 97%

CAS Number
92-43-3
Synonyms
Phenidone

Size Price ($) Quantity Availability
250g 97.20
1000g 319.00
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1-Phenyl-3-pyrazolidinone, 97%

MDL
MFCD00003094
EINECS
202-155-1

Chemical Properties

Formula
C9H10N2O
Formula Weight
162.19
Melting point
120-123°
Solubility
Soluble in water (1:10 hot), methanol (0.1 mg/mL), DMSO (75 mg/mL), and ethanol.

Applications

Phenidone inhibits both the LO (lipoxygenase) and Cox (cyclooxygenase) pathways, the synthesis of Fos-related antigen protein, and is described as an anti-inflammatory and anti-oxidant compound. Phenidone has been shown to block neurotoxicity induced by kainate, and weakens oxidative stress induced by lipopolysaccharide.

Notes

Store in cool place. Keep away from oxidizing agents.

Literature References

Dennis J. Hlasta.; Francis B. Casey.; Edward W. Ferguson.; Sally J. Gangell.; Martha R. Heimann.; Edward P. Jaeger.; Rudolph K. Kullnig.; Robert J. Gordon. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J. Med. Chem. 1991, 34 (5),1560-1570.

Hong-Jun Wang.; Jeffrey Keilman.; Chittari Pabba.; Zhen-Jia Chen.; Brian T. Gregg. Microwave-assisted cross-coupling of 3-chloro-2-pyrazolines and 3-chloro-1-phenyl-1,4,5,6-tetrahydropyridazine with aryl boronic acids. Tetrahedron Lett. 2005, 46 (15),2631-2634.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264-P270-P301+P312a-P330-P501a

Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Rinse mouth. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,7309
Beilstein
131856
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2933.19
TSCA
Yes
RTECS
UQ8750000

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