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Isobutyraldehyde is used as an intermediate in the preparation of isobutanol, methacrolein, hydroxypivaldehyde and neopentyl glycol. It is actively involved in the Cannizaro reaction. It is also used as an intermediate to prepare pharmaceuticals, agrochemicals, vitamins, antioxidants, rubber accelerators, textile auxiliaries, perfumery and flavors.
Renzetti, A.; Marrone, A.; Gérard, S.; Sapi, J.; Nakazawa, H.; Re, N.; Fontana, A. TiCl4-promoted condensation of methyl acetoacetate, isobutyraldehyde, and indole: a theoretical and experimental study. Phys. Chem. Chem. Phys. 2015, 17 (14), 8964-8972.
Fu, A.; Zhao, C.; Li, H.; Tian, C.; Chu, T.; Tian, F.; Liu, J.; Wang, Z.; Duan, Y. Theoretical investigation on the chemo-and stereoselectivities of isoleucine-catalyzed cross-aldol reactions between two enolizable aldehydes involving isobutyraldehyde and contrasts with proline catalysis. Tetrahedron: Asymmetry 2014, 25 (5), 418-428.
Hazard Statements: H225-H303-H319-H335
Highly flammable liquid and vapour. May be harmful if swallowed. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.