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A12107 N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride, 98+%

CAS Number
1,4-Bis(dimethylamino)benzene dihydrochloride
Wurster's Blue dihydrochloride

Stock No. Size Price ($) Quantity Availability
A12107-09 10g 50.90
A12107-18 50g 187.00
A12107-30 250g 787.00
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N,N,N',N'-Tetramethyl-p-phenylenediamine dihydrochloride, 98+%


Chemical Properties

Formula Weight
Melting point
ca 228° dec.
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Soluble in dimethyl sulfoxide, water and phosphate buffered saline at pH 7.2.


N,N,N',N'-tetramethyl-p-phenylenediamine dihydrochloride (TMPD) is an oxidizable compound that serves as a reducing co-substrate for heme peroxidases. It is also used as a test reagent in microbiology for the classification of cytochrome oxidase positive aerobic microorganisms. It finds application as a detection of peroxidases on polyacrylamide gels.


Light sensitive. Incompatible with strong oxidizing agents.                    

Literature References

Zoll, J.; Bouitbir, J.; Sirvent, P.; Klein, A.; Charton, A.; Jimenez, L.; Péronnet, F. R.; Geny, B.; Richard, R. apparent Km of mitochondria for oxygen computed from Vmax measured in permeabilized muscle fibers is lower in water enriched in oxygen by electrolysis than injection. Drug Des. Devel. Ther. 2015, 9, 3589-3597.

Lejay, A.; Choquet, P.; Thaveau, F.; Singh, F.; Schlagowski, A.; Charles, A. L.; Laverny, G.; Metzger, D.; Zoll, J.; Chakfe, N. A New Murine Model of Sustainable and Durable Chronic Critical Limb Ischemia Fairly Mimicking Human Pathology. Eur. J. Vasc. Endovasc. 2015, 49 (2), 205-212.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

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