I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.
Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.
Chloride source giving a high degree of stereoselectivity in the ring opening of epoxy alcohols mediated by Titanium(IV) isopropoxide, A13703: Chem. Lett., 357 (1989).
The Willgerodt reaction can be carried out at steam-bath temperature by the use of dimethylamine hydrochloride and sodium acetate in DMF in place of Morpholine, A10355: Synthesis, 730 (1983).
Reductive amination of aldehydes and ketones occurs with titanium isopropoxide followed by sodium borohydride, giving a convenient route to N,N-dimethylated tertiary amines: J. Org. Chem., 60, 4928 (1995).
Nortcliffe, A.; Moody, C. J. Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry. Bioorg Med Chem 2015, 23 (11), 2730-2735.
Lan, J. S.; Pan, L. F.; Xie, S. S.; Wang, X. B.; Kong, L. Y. Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors. Med. Chem. Commun. 2015, 6 (4), 592-600.
Hazard Statements: H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.