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506-59-2 - Dimethylamine hydrochloride, 98+% - Dimethylammonium chloride - A12133 - Alfa Aesar

A12133 Dimethylamine hydrochloride, 98+%

CAS Number
506-59-2
Synonyms
Dimethylammonium chloride

Size Price ($) Quantity Availability
250g 20.21
1000g 57.15
5000g 234.00
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Dimethylamine hydrochloride, 98+%

MDL
MFCD00012477
EINECS
208-046-5

Chemical Properties

Formula
(CH3)2NH•HCl
Formula Weight
81.55
Melting point
168-174°
Sensitivity
Hygroscopic
Solubility
Soluble in water, alcohol and chloroform

Applications

Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.

Notes

Hygroscopic. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agent.

Literature References

Chloride source giving a high degree of stereoselectivity in the ring opening of epoxy alcohols mediated by Titanium(IV)­ isopropoxide, A13703: Chem. Lett., 357 (1989).

The Willgerodt reaction can be carried out at steam-bath temperature by the use of dimethylamine hydrochloride and sodium acetate in DMF in place of Morpholine, A10355: Synthesis, 730 (1983).

Reductive amination of aldehydes and ketones occurs with titanium isopropoxide followed by sodium borohydride, giving a convenient route to N,N-dimethylated tertiary amines: J. Org. Chem., 60, 4928 (1995).

Nortcliffe, A.; Moody, C. J. Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry. Bioorg Med Chem 2015, 23 (11), 2730-2735.

Lan, J. S.; Pan, L. F.; Xie, S. S.; Wang, X. B.; Kong, L. Y. Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors. Med. Chem. Commun. 2015, 6 (4), 592-600.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,3228
Beilstein
3589311
Harmonized Tariff Code
2921.11
TSCA
Yes
RTECS
IQ0220000

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