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A12133 Dimethylamine hydrochloride, 98+%

CAS Number
506-59-2
Synonyms
Dimethylammonium chloride

Stock No. Size Price ($) Quantity Availability
A12133-30 250g 22.60
A12133-0B 1000g 62.90
A12133-0I 5000g 273.00
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Dimethylamine hydrochloride, 98+%

MDL
MFCD00012477
EINECS
208-046-5

Chemical Properties

Formula
(CH3)2NH•HCl
Formula Weight
81.55
Melting point
168-174°
Storage & Sensitivity
Hygroscopic. Ambient temperatures.
Solubility
Soluble in water, alcohol and chloroform

Applications

Dimethylamine hydrochloride is used as an intermediate in the manufacture of pharmaceuticals like ranitidine and metformin, tramadol and amlodipine. It is used as a precursor of atrazine. It is associated with sodium acetate and used to carry out the Willgerodt- Kindler reaction to prepare amides. Its free base reacts with carbon disulfide to get dimethyldithiocarbamate which is used in rubber vulcanization. It is involved in the synthesis of dimethyl-(1-methyl-pyrrol-2-ylmethyl)-amine by reacting with 1-methyl pyrrole and formaldehyde.

Notes

Hygroscopic. Keep container tightly closed in a dry and well-ventilated place. Incompatible with oxidizing agent.

Literature References

Chloride source giving a high degree of stereoselectivity in the ring opening of epoxy alcohols mediated by Titanium(IV)­ isopropoxide, A13703: Chem. Lett., 357 (1989).

The Willgerodt reaction can be carried out at steam-bath temperature by the use of dimethylamine hydrochloride and sodium acetate in DMF in place of Morpholine, A10355: Synthesis, 730 (1983).

Reductive amination of aldehydes and ketones occurs with titanium isopropoxide followed by sodium borohydride, giving a convenient route to N,N-dimethylated tertiary amines: J. Org. Chem., 60, 4928 (1995).

Nortcliffe, A.; Moody, C. J. Seven-membered ring scaffolds for drug discovery: Access to functionalised azepanes and oxepanes through diazocarbonyl chemistry. Bioorg Med Chem 2015, 23 (11), 2730-2735.

Lan, J. S.; Pan, L. F.; Xie, S. S.; Wang, X. B.; Kong, L. Y. Synthesis and evaluation of 6-methylcoumarin derivatives as potent and selective monoamine oxidase B inhibitors. Med. Chem. Commun. 2015, 6 (4), 592-600.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,3228
Beilstein
3589311
Harmonized Tariff Code
2921.11
TSCA
Yes
RTECS
IQ0220000

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