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A12197 6-Mercaptopurine monohydrate, 98%

CAS Number
6-Purinethiol monohydrate

Stock No. Size Price ($) Quantity Availability
A12197-03 1g 21.80
A12197-06 5g 65.70
A12197-14 25g 235.00
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6-Mercaptopurine monohydrate, 98%


Chemical Properties

Formula Weight
170.19 (152.17anhy)
Melting point
ca 315° dec.
Storage & Sensitivity
Ambient temperatures.
Soluble in dilute solutions of alkali hydroxides, hot alcohol, and 1 N NaOH (50 mg/ml). Insoluble in water.


6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.


Store in cool, dry place, in well sealed container. Store away from oxidizing agents.

Literature References

K. D. Senali Abayratna Wansa; Jonathan M. Harris; Grace Yan; Peter Ordentlich and George E. O. Muscat. The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine. The Journal of Biological Chemistry. 1986, 278, 24776-24790.

John A. Montgomery; Thomas P. Johnston; Anne Gallagher; Carl R. Stringfellow; Frank M. SchabelJr. A Comparative Study of the Anticancer Activity of Some S-Substituted Derivatives of 6-Mercaptopurine and their Ribonucleosides. J. Med. Chem. 1960, 3 (2), 265-288.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335-H341-H361

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.

Precautionary Statements: P202-P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P308+P313-P312-P330-P332+P313-P337+P313-P362-P501c

Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code


  • A10173

    Trifluoromethanesulfonic acid, 98+%
  • A11698

    4-Ethylbenzoyl chloride, 98+%
  • A12586

    Diphenyl disulfide, 98%
  • A14254

    2,2,6-Trimethyl-1,3-dioxin-4-one, cont. up to ca 6% acetone
  • 11186

    Yttrium(III) acetate tetrahydrate, REacton®, 99.99% (REO)

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