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6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.
K. D. Senali Abayratna Wansa; Jonathan M. Harris; Grace Yan; Peter Ordentlich and George E. O. Muscat. The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine. The Journal of Biological Chemistry. 1986, 278, 24776-24790.
John A. Montgomery; Thomas P. Johnston; Anne Gallagher; Carl R. Stringfellow; Frank M. SchabelJr. A Comparative Study of the Anticancer Activity of Some S-Substituted Derivatives of 6-Mercaptopurine and their Ribonucleosides. J. Med. Chem. 1960, 3 (2), 265-288.
Hazard Statements: H302-H341-H361
Harmful if swallowed. Suspected of causing genetic defects. Suspected of damaging fertility or the unborn child.
Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.