Cookies disclaimer

I agree Our site saves small pieces of text information (cookies) on your device in order to deliver better content and for statistical purposes. You can disable the usage of cookies by changing the settings of your browser. By browsing our website without changing the browser settings you grant us permission to store that information on your device.

300-87-8 - 3,5-Dimethylisoxazole, 99% - A12217 - Alfa Aesar

A12217 3,5-Dimethylisoxazole, 99%

CAS Number
300-87-8
Synonyms

Size Price ($) Quantity Availability
25g 38.16
100g 133.90
Add to Cart Add to Quote Request View Item

3,5-Dimethylisoxazole, 99%

MDL
MFCD00003156
EINECS
206-100-2

Chemical Properties

Formula
C5H7NO
Formula Weight
97.12
Melting point
-14°
Boiling Point
142-144°
Flash Point
31°(87°F)
Density
0.992
Refractive Index
1.4415
Solubility
Insoluble in water.

Applications

The optimization of 3,5-dimethylisoxazole derivatives to develop potent inhibitors of the BET (bromodomain and extra terminal domain) bromodomain family with good ligand efficiency. It has hypoglycemic activity.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Hewings DS; Fedorov O; Filippakopoulos P.; Martin S.; Picaud S.; Tumber A.; Wells C.; Olcina MM.; Freeman K.; Gill A.; Ritchie AJ.; Sheppard DW.; Russell AJ.; Hammond EM; Knapp S; Brennan PE; Conway SJ.Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J Med Chem. 2013, 56 (8), 3217-27.

William E. Dulin; George C. Gerritsen. Hypoglycemic Activity of 3,5 Dimethylisoxazole. Exp Biol Med. 1963, 113 (3), 683-685.

Lithiation occurs first at the 5-methyl group. Subsequent reaction with electrophiles can be followed by further lithiation of the 3-methyl, providing a route to substituted isoxazoles, and also to 1,3-diketones by acid hydrolysis or ß-aminoketones by hydrogenolysis: Tetrahedron Lett., 22, 3699 (1981):

Review: Reaction of 3,5-dimethylisoxazole with some electrophiles: Heterocycles, 6, 805 (1977).

GHS Hazard and Precautionary Statements

Hazard Statements: H226

Flammable liquid and vapour.

Precautionary Statements: P210-P280-P240-P241-P233-P242-P243-P303+P361+P353-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Keep container tightly closed. Use only non-sparking tools. Take precautionary measures against static discharge. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
106324
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2934.99
TSCA
Yes
RTECS
NY2774200

Recommended

  • 11034

    Palladium(II) chloride, 99.9% (metals basis), Pd 59.0% min

Recently Viewed

Chemicals

Life Science

Metals & Materials

Catalysts

Analytical & Labware