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A12290 3-Chloropropiophenone, 96%

CAS Number
936-59-4
Synonyms
2-Chloroethyl phenyl ketone
beta-Chloropropiophenone

Stock No. Size Price ($) Quantity Availability
A12290-09 10g 41.90
A12290-18 50g 154.00
A12290-22 100g 263.00
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3-Chloropropiophenone, 96%

MDL
MFCD00000990
EINECS
213-317-6

Chemical Properties

Formula
C9H9ClO
Formula Weight
168.62
Melting point
46-50°
Boiling Point
113-115°/4mm
Flash Point
>110°(230°F)
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

3-Chloropropiophenone was used in the asymmetric reduction of (S)-3-chloro-1-phenylpropanol using preheated Candida utilis cells immobilized in calcium alginate gel beads. It was also used in the synthesis of (R)-3-chloro-1-phenyl-1-propanol via asymmetric reduction using in-situ generated oxazaborolidine catalyst derived from (S)-α,α-diphenylprolinol. It is a precursor of phenyl vinyl ketone.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Literature References

Yang Gen-Sheng; Xu Jiang-Yan; Ou Zhi-Min; Yao Shan-Jing. Asymmetric reduction of (S)-3-chloro-1-phenylpropanol from 3-chloropropiophenone by preheated immobilized Candida utilis. Biotechnology Letters. 2009, 31 (12), 1879-1883.

Yu-Chang Liu; Yan Liu; Zhong-Liu Wu. Synthesis of enantiopure glycidol derivatives via a one-pot two-step enzymatic cascade. Organic & Biomolecular Chemistry. 2015, 13 (7), 2146-2152.

Precursor of phenyl vinyl ketone.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2043580
Harmonized Tariff Code
2914.79
TSCA
Yes

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