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Sodium chloroacetate is used to prepare dyes and active pharmaceutical ingredients. It is also used as an odor agent, surface active agent and viscosity adjustor.
A convenient method for the conversion of arylamines to the corresponding N,N-diacetic acids is by lithiation followed by reaction with sodium chloroacetate. For discussion and limitations, see: Synthesis, 548 (1989).
Ding, F.; Qian, X.; Zhang, Q.; Wu, H.; Liu, Y.; Xiao, L.; Deng, H.; Du, Y.; Shi, X. Electrochemically induced reversible formation of carboxymethyl chitin hydrogel and tunable protein release. New J. Chem. 2015, 39 (2), 1253-1259.
Zhang, A.; Cheng, L.; Hong, S.; Yang, C.; Lin, Y. Preparation of anti-fouling silicone elastomers by covalent immobilization of carboxybetaine. RSC Adv. 2015, 5 (107), 88456-88463.
Hazard Statements: H301-H315
Toxic if swallowed. Causes skin irritation.
Precautionary Statements: P264b-P270-P280-P301+P310-P302+P352-P305+P351+P338-P330-P332+P313-P362-P501c
Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant