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Ethyl 3-bromopropionate was used in the preparation of (3?,4?-dimethoxyphenyl)-5-oxopentanoic acid.
Berlin KD,; Herd MD. Proc. Novel 2-amino-4-aryl-substituted-and 2-amino-4, 5-disubstituted-thiazoles.Oklahoma Acad. Sci. 1991, 71 29-33
Undergoes a "homo-Reformatsky" coupling with carbonyl compounds leading to -lactones. The homoenolate can be generated with various lanthanide metals, La, Ce, Nd or Sm: J. Org. Chem., 55, 1628 (1990):
Cyclopropanols may be synthesized by reaction of ß-halo esters with Grignard reagents and SmI2: Tetrahedron Lett., 32, 7691 (1991).
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.