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504-24-5 - 4-Aminopyridine, 98% - Fampridine - 4-Pyridinamine - A12405 - Alfa Aesar

A12405 4-Aminopyridine, 98%

CAS Number
504-24-5
Synonyms
Fampridine
4-Pyridinamine

Size Price ($) Quantity Availability
50g 53.25
250g 186.10
1000g 566.40
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4-Aminopyridine, 98%

MDL
MFCD00006439
EINECS
207-987-9

Chemical Properties

Formula
C5H6N2
Formula Weight
94.12
Melting point
157-161°
Boiling Point
273-274°
Flash Point
164°(327°F)
Density
1.26
Solubility
Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.

Applications

It is used as a research tool, in characterizing subtypes of the potassium channel. It has also been used as a drug, to manage some of the symptoms of multiple sclerosis. In the laboratory, 4-AP is a useful pharmacological tool in studying various potassium conductances in physiology and biophysics. Spinal cord injury patients have also seen improvement with 4-AP therapy.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

H Bostock et. al.The effects of 4-aminopyridine and tetraethylammonium ions on normal and demyelinated mammalian nerve fibres. Journal of Physiology. 1981, 313 301-315.

Shun-ichi Yamaguchi,; Michael A. Rogawski.Effects of anticonvulsant drugs on 4-aminopyridine-induced seizures in mice . Epilepsy Research. 1992, 11(1), 9-16.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H311-H315-H319-H335-H411-H401

Fatal if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Toxic to aquatic life with long lasting effects. Toxic to aquatic life.

Precautionary Statements: P273-P280h-P270-P301+P310-P305+P351+P338-P302+P352

Avoid release to the environment. Wear protective gloves/clothing. Do not eat, drink or smoke when using this product. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF ON SKIN: Wash with plenty of soap and water.

Other References

Merck
14,3933
Beilstein
105782
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2933.39
TSCA
Yes
RTECS
US1750000

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