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A12410 Iodoacetic acid, 97+%

CAS Number
64-69-7
Synonyms

Stock No. Size Price ($) Quantity Availability
A12410-14 25g 55.10
A12410-22 100g 170.00
A12410-36 500g 680.00
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Iodoacetic acid, 97+%

MDL
MFCD00002685
EINECS
200-590-1

Chemical Properties

Formula
ICH2CO2H
Formula Weight
185.95
Melting point
79-82°
Boiling Point
208° dec.
Storage & Sensitivity
Keep Cold. Light Sensitive.
Solubility
Soluble in water, alcohol and ethanol. Slightly soluble in ether and chloroform.

Applications

Iodoacetic acid is used as a reagent for the modification of sulfhydryl groups in organic synthesis. It reacts with cysteine moiety in proteins to prevent the re-formation of disulfide bonds during protein sequencing. It is also used as a general reagent in acylation reactions as well as in glycopeptide synthesis.

Notes

Light sensitive. Store in cool place. Incompatible with strong oxidizing agents, bases and strong reducing agents.

Literature References

Shimada, T.; Kuyama, H.; Sato, T. A.; Tanaka, K. Development of iodoacetic acid-based cysteine mass tags: detection enhancement for cysteine-containing peptide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal. Biochem. 2012, 421 (2), 785-787.

Scott, P. A.; Kaplan, H. J.; Sandell, J. H. Anatomical evidence of photoreceptor degeneration induced by iodoacetic acid in the porcine eye. Exp Eye Res 2011, 93 (4), 513-527.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H314

Toxic if swallowed. Causes severe skin burns and eye damage.

Precautionary Statements: P260-P264b-P270-P280-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Rinse mouth. Do NOT induce vomiting. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,5025
Beilstein
1739079
Hazard Class
8
Packing Group
I
Harmonized Tariff Code
2915.90
TSCA
Yes
RTECS
AI3500000

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