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64-69-7 - Iodoacetic acid, 97+% - A12410 - Alfa Aesar

A12410 Iodoacetic acid, 97+%

CAS Number
64-69-7
Synonyms

Size Price ($) Quantity Availability
25g 49.96
100g 163.77
500g 615.41
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Iodoacetic acid, 97+%

MDL
MFCD00002685
EINECS
200-590-1

Chemical Properties

Formula
ICH2CO2H
Formula Weight
185.95
Melting point
79-82°
Boiling Point
208° dec.
Sensitivity
Light Sensitive
Solubility
Soluble in water, alcohol and ethanol. Slightly soluble in ether and chloroform.

Applications

Iodoacetic acid is used as a reagent for the modification of sulfhydryl groups in organic synthesis. It reacts with cysteine moiety in proteins to prevent the re-formation of disulfide bonds during protein sequencing. It is also used as a general reagent in acylation reactions as well as in glycopeptide synthesis.

Notes

Light sensitive. Store in cool place. Incompatible with strong oxidizing agents, bases and strong reducing agents.

Literature References

Shimada, T.; Kuyama, H.; Sato, T. A.; Tanaka, K. Development of iodoacetic acid-based cysteine mass tags: detection enhancement for cysteine-containing peptide by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal. Biochem. 2012, 421 (2), 785-787.

Scott, P. A.; Kaplan, H. J.; Sandell, J. H. Anatomical evidence of photoreceptor degeneration induced by iodoacetic acid in the porcine eye. Exp Eye Res 2011, 93 (4), 513-527.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H314

Toxic if swallowed. Causes severe skin burns and eye damage.

Precautionary Statements: P260-P280-P301+P310-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,5025
Beilstein
1739079
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
Yes
RTECS
AI3500000

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