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A12435 Methyl 2-bromobenzoate, 99%

CAS Number
610-94-6
Synonyms
2-Bromobenzoic acid methyl ester

Stock No. Size Price ($) Quantity Availability
A12435-14 25g 30.50
A12435-22 100g 110.00
A12435-36 500g 470.00
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Methyl 2-bromobenzoate, 99%

MDL
MFCD00016328
EINECS
210-241-5

Chemical Properties

Formula
C8H7BrO2
Formula Weight
215.05
Boiling Point
252°
Flash Point
>110°(230°F)
Density
1.532
Refractive Index
1.5590
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

Methyl 2-bromobenzoate under Heck reaction with acrylonitrile results in lactonization to give the benzofuran-2-one 3-(cyanomethyl)-2-coumaranone. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals

Notes

Store in a cool place. Keep away from oxidizing agents.

Literature References

Stephan Thorand.; Norbert Krause. Improved Procedures for the Palladium-Catalyzed Coupling of Terminal Alkynes with Aryl Bromides (Sonogashira Coupling). J. Org. Chem. 1998, 63 (23),8551-8553.

Carsten Bolm.; Jens P. Hildebrand. Palladium-catalyzed carbon?nitrogen bond formation: A novel, catalytic approach towards N-arylated sulfoximines. Tetrahedron Lett.. 1998, 39 (32),5731-5734.

Heck reaction with acrylonitrile results in lactonization to give the benzofuran-2-one 3-(cyanomethyl)-2-coumaranone: J. Heterocycl. Chem., 32, 1587 (1995):

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1862501
Harmonized Tariff Code
2916.39
TSCA
Yes

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