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Fluorimetric reagent and major catecholamine metaboliteHomovanillic acid is used as a reagent in the determination of oxidative enzymes. It is associated with dopamine levels in the brain. Its presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.
Reagent for the determination of enzymes: Anal. Chem., 40, 190 (1968), and amino acids: Anal. Biochem., 26, 1 (1968).
Remane, D.; Grunwald, S.; Hoeke, H.; Mueller, A.; Roeder, S.; von Bergen, M.; Wissenbach, D. K. Validation of a multi-analyte HPLC-DAD method for determination of uric acid, creatinine, homovanillic acid, niacinamide, hippuric acid, indole-3-acetic acid and 2-methylhippuric acid in human urine. J. Chromatogr. B 2015, 998-999, 40-44.
Miura, I.; Kanno-Nozaki, K.; Hino, M.; Horikoshi, S.; Ota, T.; Mashiko, H.; Niwa, S. I.; Yabe, H. Influence of -141C Ins/Del Polymorphism in DRD2 Gene on Clinical Symptoms and Plasma Homovanillic Acid Levels in the Treatment of Schizophrenia With Aripiprazole. J. Clin. Psychopharmacol. 2015, 35 (3), 333-334.