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306-08-1 - Homovanillic acid, 98+% - 4-Hydroxy-3-methoxyphenylacetic acid - A12441 - Alfa Aesar

A12441 Homovanillic acid, 98+%

CAS Number
306-08-1
Synonyms
4-Hydroxy-3-methoxyphenylacetic acid

Size Price ($) Quantity Availability
1g 54.38
5g 170.98
25g 457.60
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Homovanillic acid, 98+%

MDL
MFCD00004350
EINECS
206-176-7

Chemical Properties

Formula
C9H10O4
Formula Weight
182.18
Melting point
140-145°
Solubility
Soluble in water,dimethyl sulfoxide, ethanol, methanol and ethyl acetate.

Applications

Fluorimetric reagent and major catecholamine metaboliteHomovanillic acid is used as a reagent in the determination of oxidative enzymes. It is associated with dopamine levels in the brain. Its presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.

Notes

Light sensitive. Store in a cool place. Incompatible with strong oxidizing agents.

Literature References

Reagent for the determination of enzymes: Anal. Chem., 40, 190 (1968), and amino acids: Anal. Biochem., 26, 1 (1968).

Remane, D.; Grunwald, S.; Hoeke, H.; Mueller, A.; Roeder, S.; von Bergen, M.; Wissenbach, D. K. Validation of a multi-analyte HPLC-DAD method for determination of uric acid, creatinine, homovanillic acid, niacinamide, hippuric acid, indole-3-acetic acid and 2-methylhippuric acid in human urine. J. Chromatogr. B 2015, 998-999, 40-44.

Miura, I.; Kanno-Nozaki, K.; Hino, M.; Horikoshi, S.; Ota, T.; Mashiko, H.; Niwa, S. I.; Yabe, H. Influence of -141C Ins/Del Polymorphism in DRD2 Gene on Clinical Symptoms and Plasma Homovanillic Acid Levels in the Treatment of Schizophrenia With Aripiprazole. J. Clin. Psychopharmacol. 2015, 35 (3), 333-334.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4740
Beilstein
2213447
Harmonized Tariff Code
2918.99
TSCA
Yes

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