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It is a potassium channel blocker in nerve terminals. It inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.
J. M. Rubin-Preminger.; U. Englert. 3,4-Diaminopyridine Acta Cryst. 2007, 63 (2),o757-o758 .
Jorge Molgó.; H?kan Lundh.; Stephen Thesleff. Potency of 3,4-Diaminopyridine and 4-aminopyridine on mammalian neuromuscular transmission and the effect of pH changes. Eur. J. Pharmacol. 1980, 61 (1),25-34.
Hazard Statements: H300-H311-H315-H318-H330-H335
Fatal if swallowed. Toxic in contact with skin. Causes skin irritation. Causes serious eye damage. Fatal if inhaled. May cause respiratory irritation.
Precautionary Statements: P260-P264b-P270-P271-P280-P284-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P361-P363-P501c
Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. Wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant