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It is a potassium channel blocker in nerve terminals. It inhibits potassium channel efflux, increasing the duration of the action potential, which results in an increase in the duration of calcium channel opening and enhanced acetylcholine (ACh) release. Increased ACh availability at the motor end plate allows muscles to contract.
J. M. Rubin-Preminger.; U. Englert. 3,4-Diaminopyridine Acta Cryst. 2007, 63 (2),o757-o758 .
Jorge Molgó.; H?kan Lundh.; Stephen Thesleff. Potency of 3,4-Diaminopyridine and 4-aminopyridine on mammalian neuromuscular transmission and the effect of pH changes. Eur. J. Pharmacol. 1980, 61 (1),25-34.
Hazard Statements: H300-H312-H330-H319
Fatal if swallowed. Harmful in contact with skin. Fatal if inhaled. Causes serious eye irritation.
Precautionary Statements: P280h-P304+P340-P305+P351+P338-P320-P310a-P302+P352a
Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment is urgent (see label). IF ON SKIN: