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A12468 Isatin, 98%

CAS Number
91-56-5
Synonyms
2,3-Indolinedione

Stock No. Size Price ($) Quantity Availability
A12468-22 100g 22.50
A12468-36 500g 79.00
A12468-0E 2500g 304.00
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Isatin, 98%

MDL
MFCD00005718
EINECS
202-077-8

Chemical Properties

Formula
C8H5NO2
Formula Weight
147.13
Melting point
ca 199-200°
Flash Point
220°(428°F)
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water (1.9 g/L at 20°C).

Applications

Isatin is an endogenous monoamine oxidize (MAO) inhibitor involved in stress and anxiety. Additionally, isatin inhibits alkaline phosphatase (ALP), nitric oxide (NO)-stimulated soluble guanylate cyclase, and other enzymes. Isatins undergo a one-pot Wolff-Kishner like reduction with hydrazine hydrate, under surprisingly mild conditions, to give the corresponding oxindoles. It is used as chromatographic spray reagent for amino acid detection.

Notes

Store under cool dry place. Ensure good ventilation. Incompatible with oxidizing agents.

Literature References

Seshaiah Krishnan Sridhar.; Surendra N Pandey.; James P Stables.; Atmakuru Ramesh. Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives. European Journal of Pharmaceutical Sciences. 2002, 16 (3),129-132.

S.N. Pandeya.; D. Sriram.; G. Nath.; E. DeClercq. Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4?-chlorophenyl)thiazol-2-yl] thiosemicarbazide. European Journal of Pharmaceutical Sciences. 1999, 9 (1),25-31.

Isatins undergo a one-pot Wolff-Kishner like reduction with hydrazine hydrate, under surprisingly mild conditions, to give the corresponding oxindoles: Synth. Commun., 24, 2835 (1994).

Reaction with acid anhydrides or condensation with 4-Methyl-2-pentanone, A11618, results in the formation of quinoline-4-carboxylic acid derivatives; for examples, see: J. Med. Chem., 35, 4893 (1992); 36, 617, 3286 (1993).:

GHS Hazard and Precautionary Statements

Hazard Statements: H360

May damage fertility or the unborn child.

Precautionary Statements: P201-P202-P280-P308+P313-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wear protective gloves/protective clothing/eye protection/face protection. IF exposed or concerned: Get medical advice/attention. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,5104
Beilstein
383659
Harmonized Tariff Code
2933.79
TSCA
Yes
RTECS
NL7873000

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