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91-56-5 - Isatin, 98% - 2,3-Indolinedione - A12468 - Alfa Aesar

A12468 Isatin, 98%

CAS Number
91-56-5
Synonyms
2,3-Indolinedione

Size Price ($) Quantity Availability
100g 21.22
500g 75.19
2500g 294.58
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Isatin, 98%

MDL
MFCD00005718
EINECS
202-077-8

Chemical Properties

Formula
C8H5NO2
Formula Weight
147.13
Melting point
ca 199-200°
Flash Point
220°(428°F)
Solubility
Soluble in water (1.9 g/L at 20°C).

Applications

Isatin is an endogenous monoamine oxidize (MAO) inhibitor involved in stress and anxiety. Additionally, isatin inhibits alkaline phosphatase (ALP), nitric oxide (NO)-stimulated soluble guanylate cyclase, and other enzymes. Isatins undergo a one-pot Wolff-Kishner like reduction with hydrazine hydrate, under surprisingly mild conditions, to give the corresponding oxindoles. It is used as chromatographic spray reagent for amino acid detection.

Notes

Store under cool dry place. Ensure good ventilation. Incompatible with oxidizing agents.

Literature References

Seshaiah Krishnan Sridhar.; Surendra N Pandey.; James P Stables.; Atmakuru Ramesh. Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives. European Journal of Pharmaceutical Sciences. 2002, 16 (3),129-132.

S.N. Pandeya.; D. Sriram.; G. Nath.; E. DeClercq. Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4?-chlorophenyl)thiazol-2-yl] thiosemicarbazide. European Journal of Pharmaceutical Sciences. 1999, 9 (1),25-31.

Isatins undergo a one-pot Wolff-Kishner like reduction with hydrazine hydrate, under surprisingly mild conditions, to give the corresponding oxindoles: Synth. Commun., 24, 2835 (1994).

Reaction with acid anhydrides or condensation with 4-Methyl-2-pentanone, A11618, results in the formation of quinoline-4-carboxylic acid derivatives; for examples, see: J. Med. Chem., 35, 4893 (1992); 36, 617, 3286 (1993).:

Other References

Merck
14,5104
Beilstein
383659
Harmonized Tariff Code
2933.79
TSCA
Yes
RTECS
NL7873000

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