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Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum. Cyanoacetamide is the starting reagent for vitamin B6 synthesis. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence andis useful for the automated analysis of carbohydrates as borate complexes.
Fadda AA, et al..; Turk. J. Cyanoacetamide derivatives as synthons in heterocyclic synthesis. J. Chem. 2008, 32 (3),259-286.
Honda S, et al. Fluorimetric determination of reducing carbohydrates with 2-cyanoacetamide and application to automated analysis of carbohydrates as borate complexes. Anal. Chem. 1980, 52 (7), 1079-1082.
Review of utility in heterocyclic synthesis: Heterocycles, 24, 2023 (1986). Reaction with various enones and enals in the presence of KO-t-Bu and oxygen in DMSO provides a one-step route to functionalized 3-cyano-2-pyridones: Tetrahedron Lett., 36, 3307 (1995):
In the absence of oxygen, only Michael addition occurs.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.