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107-91-5 - Cyanoacetamide, 99% - Malonamide nitrile - A12482 - Alfa Aesar

A12482 Cyanoacetamide, 99%

CAS Number
107-91-5
Synonyms
Malonamide nitrile

Size Price ($) Quantity Availability
100g 21.84
500g 71.19
2500g 260.10
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Cyanoacetamide, 99%

MDL
MFCD00008024
EINECS
203-531-8

Chemical Properties

Formula
NCCH2CONH2
Formula Weight
84.08
Melting point
118-122°
Flash Point
215°(419°F)
Solubility
Soluble in water.

Applications

Cyanoacetamide was used in spectrofluorimetric method for the determination of some antihistaminic H1 receptor antagonist drugs such as ebastine, cetirizine dihydrochloride and fexofenadine hydrochloride. It may be used in fluorometric determination of 3,4-dihydroxyphenylalanine. It was used as post column fluorigenic derivatizing agent for the bio-analysis and pharmacokinetics of chitosan ester in rabbit serum. Cyanoacetamide is the starting reagent for vitamin B6 synthesis. It reacts with reducing carbohydrates in borate buffer to give intense fluorescence andis useful for the automated analysis of carbohydrates as borate complexes.

Notes

Store under cool dry place. Ensure good ventilation. Incompatible with oxidizing agents.

Literature References

Fadda AA, et al..; Turk. J. Cyanoacetamide derivatives as synthons in heterocyclic synthesis. J. Chem. 2008, 32 (3),259-286.

Honda S, et al. Fluorimetric determination of reducing carbohydrates with 2-cyanoacetamide and application to automated analysis of carbohydrates as borate complexes. Anal. Chem. 1980, 52 (7), 1079-1082.

Review of utility in heterocyclic synthesis: Heterocycles, 24, 2023 (1986). Reaction with various enones and enals in the presence of KO-t-Bu and oxygen in DMSO provides a one-step route to functionalized 3-cyano-2-pyridones: Tetrahedron Lett., 36, 3307 (1995):

In the absence of oxygen, only Michael addition occurs.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2688
Beilstein
878221
Harmonized Tariff Code
2926.90
TSCA
Yes
RTECS
AB5950000

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