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A12485 Acetyl bromide, 98+%

CAS Number
506-96-7
Synonyms

Stock No. Size Price ($) Quantity Availability
A12485-14 25g 27.20
A12485-22 100g 47.20
A12485-36 500g 158.00
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Acetyl bromide, 98+%

MDL
MFCD00000114
EINECS
208-061-7

Chemical Properties

Formula
C2H3BrO
Formula Weight
122.95
Melting point
-96°
Boiling Point
75-77°
Flash Point
>75°(167°F)
Density
1.660
Refractive Index
1.4500
Storage & Sensitivity
Moisture Sensitive. Store under Nitrogen. Ambient temperatures.
Solubility
Miscible with ether, chloroform, benzene and acetone.

Applications

Acetyl Bromide is used as an acetylating agent in the synthesis of fine chemicals, agrochemicals and pharmaceuticals. It is also used as an intermediate for dyes. Further, it reacts with alcohols and amines to produce acetate esters and acetamides. In addition to this, it is involved in the synthetic process of the anti-HIV agent.

Notes

Incompatible with strong oxidizing agents, strong bases and alcohols

Literature References

In the presence of ZnCl2, adds to a wide range of aldehydes, giving ɑ-bromoalkyl acetates: Helv. Chim Acta, 61, 2047, 2059, 2165 (1978); Synthesis, 593 (1978).

In combination with TFA, OH groups can be acetylated selectively in the presence of primary and secondary amines: J. Med. Chem., 16, 630 (1973); 17, 427 (1974); Synthesis, 249 (1975).

Fukushima, R. S.; Kerley, M. S.; Ramos, M. H.; Porter, J. H.; Kallenbach, R. L. Comparison of acetyl bromide lignin with acid detergent lignin and Klason lignin and correlation with in vitro forage degradability. Anim. Feed Sci. Technol. 2015, 201, 25-37.

Grabber, J. H.; Santoro, N.; Foster, C. E.; Elumalai, S.; Ralph, J.; Pan, X. Incorporation of Flavonoid Derivatives or Pentagalloyl Glucose into Lignin Enhances Cell Wall Saccharification Following Mild Alkaline or Acidic Pretreatments. BioEnerg. Res. 2015, 8 (3), 1391-1400.

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H314

Combustible liquid. Causes severe skin burns and eye damage.

Precautionary Statements: P210-P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,82
Beilstein
1697546
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2915.90
TSCA
Yes
RTECS
AO5955000

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